Enfield was recreated for the 2002 election as a safe Labor electorate, replacing the abolished electorate of Ross Smith, and was won by Labor candidate John Rau. Rau had defeated Ralph Clarke, the former member for Ross Smith, in a Labor preselection ballot. Clarke subsequently contested the election as an independent, but came third, falling 800 votes short of the Liberal candidate. At the 2006 election, Clarke decided to contest a South Australian Legislative Council seat, for which he had very little chance of success. Without competition from Clarke, Rau extended his margin, easily retaining the electorate for Labor.
In the 2016 redistribution by the electoral districts boundaries commission, the districts southern suburbs of Collinswood and Manningham were reassigned to the neighbouring districts of Adelaide and Torrens. The districts western suburbs of Regency Park, Ferryden Park, Angle Park and Mansfield Park were reassigned to the adjacent district of Croydon. The northeastern boundary was extended to include the suburbs of Northgate, Lightsview and part of Northfield within Enfield district, and the southwestern boundary was shifted south slightly to include part of Prospect.
In both of its incarnations, Enfield has been a comfortably-safe Labor seat.