He married Emily Louise Phillips in 1893 and divorced in 1904. They had one child, Lois, who married John B.Thayer III. He married a second time in 1908 to Eleanor Blackford Smith of Virginia. She was about twenty years his junior and shared his love of horses.[3]
On the death of his father in 1906, Edward Cassatt inherited Chesterbrook Farm in Berwyn, Pennsylvania, where his father had bred Thoroughbred horses.[2] The most successful runner for Alexander Cassatt had been The Bard, a multiple Champion and winner of the 1886 Preakness Stakes. Edward Cassatt had similar success with his horse, Layminister, who won the Preakness Stakes in 1910.
Colonel Edward Cassatt died on January 31, 1922, at Chesterbrook Farm in Berwyn, Pennsylvania.[2] He was interred in the Church of the Redeemer Cemetery in Bryn Mawr, Pennsylvania.[4]