On March 11, 2014, he was signed by the Miami Dolphins to a four-year, $16 million contract including $9 million guaranteed.[3]
On September 13, 2016, Mitchell was placed on injured reserve.[4] He was activated off injured reserve to the active roster on November 10, 2016, prior to Week 10.[5]
On February 17, 2017, Mitchell was released by the Dolphins.[6]
San Francisco 49ers (first stint)
On February 24, 2017, Mitchell signed a four-year, $16 million contract with the San Francisco 49ers.[7] In his first season in San Francisco, Mitchell started all 16 games, recording 33 combined tackles, one sack, and a career-high four passes defensed.
On January 23, 2019, the 49ers declined the two-year option on Mitchell's contract, making him a free agent in 2019.[8]
Seattle Seahawks
On July 24, 2019, Mitchell was signed by the Seattle Seahawks.[9] He was released on August 31, 2019.[10]
On November 7, 2019, Mitchell announced his retirement from the NFL.[11]
San Francisco 49ers (second stint)
On January 1, 2020, Mitchell came out of retirement and signed with the 49ers.[12] Mitchell reached Super Bowl LIV with 49ers, but lost 31–20 to the Kansas City Chiefs. Mitchell recorded 1 tackle and 0.5 sacks in the Super Bowl.
Mitchell was born and raised in Houston, moving around with his mom, who separated from his dad. His grandma sometimes provided a home for him in the Trinity Garden neighborhood, but she died when Mitchell was 14 and Mitchell's dad died during his senior year in college.[14]
