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Dyclonine
Clinical data
Trade names	Sucrets
AHFS/Drugs.com	Monograph
Routes of; administration	Lozenge
ATC code	N01BX02 (WHO) R02AD04 (WHO);
Legal status
Legal status	US: OTC;
Identifiers
	IUPAC name 1-(4-butoxyphenyl)-3-(1-piperidyl)propan-1-one;
CAS Number	586-60-7 ;
PubChem CID	3180;
IUPHAR/BPS	7173;
DrugBank	DB00645 ;
ChemSpider	3068 ;
UNII	078A24Q30O;
KEGG	D07881 ;
ChEBI	CHEBI:4724 ;
ChEMBL	ChEMBL1201217 ;
CompTox Dashboard (EPA)	DTXSID6047864 ;
Chemical and physical data
Formula	C18H27NO2
Molar mass	289.419 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(c1ccc(OCCCC)cc1)CCN2CCCCC2;
	InChI InChI=1S/C18H27NO2/c1-2-3-15-21-17-9-7-16(8-10-17)18(20)11-14-19-12-5-4-6-13-19/h7-10H,2-6,11-15H2,1H3 ; Key:BZEWSEKUUPWQDQ-UHFFFAOYSA-N ;
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Dyclonine (Dyclocaine) is an oral anaesthetic that is the active ingredient of Sucrets, an over-the-counter throat lozenge.^[1] It is also found in some varieties of the Cepacol sore throat spray. It is a local anesthetic, used topically as the hydrochloride salt.^[2]

History

The product Sucrets was introduced in Baltimore, Maryland, by Sharp & Dohme in 1932.^[3]

In 1966 the Federal Trade Commission ordered Merck and Company to discontinue the false claims of germ-killing and pain-relieving properties for its Sucrets and Children's Sucrets throat lozenges.^[4] In 1977, it was acquired by Beecham, later merging with SmithKline Beckman in 1989 to form SmithKline Beecham. By 1994 the brand switched from a metal container to a plastic container.^[3] SmithKline Beecham, after announcing a merger with GlaxoWellcome to form GlaxoSmithKline, sold the brand in 2000 to Insight Pharmaceuticals. In 2011, Sucrets reintroduced their product back into the familiar tin due to popular demand and nostalgia.

References

^ Janice Jorgensen (1994). "Sucrets". Encyclopedia of Consumer Brands: Personal products. St. James Press. ISBN 9781558623378. Retrieved 2011-09-24.
^ Gargiulo AV, Burns GM, Huck CP (1992). "Dyclonine hydrochloride--a topical agent for managing pain". Illinois Dental Journal. 61 (4): 303–4. PMID 1286862.
^ ^a ^b "The Sucrets tin joins the age of plastics". USA Today. July 19, 1994. Archived from the original on 2017-08-22. Retrieved 2011-09-24.
^ "F.T.C. Bids Merck Halt Claims That Lozenges Will Kill Germs". The New York Times. Associated Press. April 19, 1966. Retrieved 2011-09-24.