Anna was married to John Sigismund on 30 October 1594. Anna was described as intellectually superior to her spouse, temperamental and strong-willed. She is reported to have thrown plates and glasses at her spouse during arguments. She fought on her own to secure her succession rights to various fiefs and handled negotiations with her competitors. In 1612, she placed her demands before the Emperor. After the conversion of her spouse to Calvinism, Anna became the protector and spokesperson of the Lutherans. She continued to play an important role during the reign of her son. She opposed the Habsburgs and secured the marriage of her daughter Maria Eleonora to King Gustavus Adolphus of Sweden against her son's will in 1620.
Issue
George William (13 November 1595 – 1 December 1640); successor of John Sigismund.