Jones was born in New York City to Mildred Jones (née Gordon). He had a sister, Marva (later Marva Brooks), and a brother, Henry.[3] He graduated from the University of Pittsburgh with a B.A. and studied at the Sorbonne in Paris, before training as an actor in New York City. He later completed an M.A. in Communications at New York University in between shooting Night of the Living Dead.
His role in the 1968 film Night of the Living Dead marked the first time an African-American actor was cast as the star and hero of a horror film, and one of the first times in American cinema where an important role was given to a Black actor when the script did not explicitly call for one, also making him the first black man in history to survive a horror movie (as opposed to the common belief that it is LL Cool J). While some saw the casting as significant, director George A. Romero stated Jones' race was not a factor in his casting; Romero cast him simply because "Jones was the best actor we met to play Ben."[4]
Jones continued working in film after Night of the Living Dead in Ganja & Hess (1973), Losing Ground (1982), and Beat Street (1984), among others.[3] Despite his other film roles, Jones worried that people only recognized him as Ben.[5]
From 1972 to 1976, Jones oversaw the literature department at Antioch College. He was subsequently executive director of the Black Theater Alliance, a federation of theater companies, from 1976 through 1981[3] and continued working as a theater actor and director, until his death in 1988. As executive director of the Richard Allen Center for Culture and Art (RACCA), he promoted African-American theater. He also taught acting styles at the American Academy of Dramatic Arts in New York City. After leaving the American Academy of Dramatic Arts, he taught a select group of students privately in Manhattan, by invitation only. His hand-selected students were of diverse ethnic backgrounds. The students were picked from his Acting Styles classes at American Academy of Dramatic Arts.