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On television, Dixon portrayed Allison Hayes in the NBC drama Berringer's.[5] She co-starred with Tom Hanks in the early 1980s situation comedy Bosom Buddies, playing the role of Sonny Lumet.[5]: 125-126
Months after they worked together in the film Doctor Detroit (1983), Dixon and actor Dan Aykroyd married. They later starred together in the films Twilight Zone: The Movie (1983) (though they did not share any scenes), Spies Like Us (1985) and The Couch Trip (1988). Dixon and Aykroyd have three daughters, among whom is singer-songwriter Vera Sola (née Danielle Aykroyd) and actor/model Belle Aykroyd.[6] The couple announced in April 2022 that they were separating after 39 years of marriage, but would remain legally married.[7]