Don Mason (immunologist)

For other people named Don Mason, see Don Mason (disambiguation).

Don Mason
Born1934 (1934)
Died13 January 2021(2021-01-13) (aged 86–87)
CitizenshipBritish
Known forWork on Regulatory T Cells
Scientific career
InstitutionsAtomic Energy Research Establishment, Sir William Dunn School of Pathology, University of Oxford

Donald W. Mason (1934 – 13 January 2021) was a British immunologist and professor of immunology in the MRC Cellular Immunology Unit at the Sir William Dunn School of Pathology at the University of Oxford. Professor Mason is best known for his work on regulatory T cells and their role in preventing autoimmunity. His distinction was recognised by his election in 2017[1] to honorary life membership of the British Society for Immunology.[2]

Notable work

Although Mason began his research career as a physicist studying controlled thermonuclear fusion,[3][4] he is best known for his work on cellular immunology, summarised in outline here.[5][6][7][8] Mason's most important contributions to immunology were his studies defining the existence, cell surface phenotype and function of regulatory T cells. Mason's research identified the immuno-regulatory capacity of a population of CD4+ T cells that express low levels of OX22 (an isoform of CD45: CD45RC in rats and CD45RB in mice[9]) and their capacity to prevent the pathogenic activity of the OX22hi subset.[10] While he carried out studies into multiple sclerosis,[11] the work for which he is most recognised focused mainly on the role of Tregs in the prevention of diabetes[12] and thyroiditis[13] and highlighted the role for the thymus in the development of Tregs.[14][9] These were among the earliest demonstrations of the requirement for Treg in restraining the pathogenic activity of CD4+ T cells and prevention of autoimmunity.[15] Mason retired from research in 1999.[8]

Personal life

Mason was a vegan and a Quaker.[6] He became a vegan in 1977.[8] In 2006, he authored Science, Mystical Experience and Religious Belief: A Personal View.[16] This contains his reflections on the scope and limitations of science, and his contemplations of "The Broader View".[17]

Mason died aged 86 on 13 January 2021.[6]

Selected publications

  • Science, Mystical Experience and Religious Belief: A Personal View (2006)

References

  1. ^ "New Honorary Members for BSI". British Society for Immunology. Retrieved 21 January 2021.
  2. ^ "Honorary members | British Society for Immunology".
  3. ^ Gibson, A.; Mason, D.W. (1962). "Energy Loss Processes in ZETA". Proceedings of the Physical Society. 79 (2): 326–350. Bibcode:1962PPS....79..326G. doi:10.1088/0370-1328/79/2/312.
  4. ^ Gibson, A.; Mason, D.W. (1969). "Binary Collision Losses in Stellarators". Plasma Physics. 11 (2): 121–129. Bibcode:1969PlPh...11..121G. doi:10.1088/0032-1028/11/2/004.
  5. ^ Seddon, B.; Powrie, F.; Barclay, N. (2021). "Don Mason (1934-2021)". Nature Immunology. 22 (4): 395. doi:10.1038/s41590-021-00884-7. Retrieved 15 March 2021.
  6. ^ a b c "Leading Immunologist and Dunn School Alumnus Don Mason - Obituary".
  7. ^ "Behind the picture: Don Mason and his T cell legacy". Medical Research Council. Retrieved 15 March 2021.
  8. ^ a b c "Don Mason Obituary". The Guardian. Retrieved 15 March 2021.
  9. ^ a b Saoudi A, Seddon B, Heath V, Fowell D, Mason D (1996). "The physiological role of regulatory T cells in the prevention of autoimmunity: the function of the thymus in the generation of the regulatory T cell subset". Immunological Reviews. 149: 195–216. doi:10.1111/j.1600-065x.1996.tb00905.x. PMID 9005215. S2CID 40160832.
  10. ^ Powrie F, Mason D (1990). "OX-22high CD4+ T cells induce wasting disease with multiple organ pathology: prevention by the OX-22low subset". Journal of Experimental Medicine. 172 (6): 1701–8. doi:10.1084/jem.172.6.1701. PMC 2188779. PMID 2258700.
  11. ^ Esther M. Sternberg (2001), The Balance Within: The Science Connecting Health and Emotions, USA: Times Books, p. 97, ISBN 978-0-7167-4445-0
  12. ^ Fowell D, Mason D (1993). "Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes. Characterization of the CD4+ T cell subset that inhibits this autoimmune potential". Journal of Experimental Medicine. 177 (3): 627–36. doi:10.1084/jem.177.3.627. PMC 2190953. PMID 8094734.
  13. ^ Seddon B, Mason D (1999). "Regulatory T cells in the control of autoimmunity: the essential role of transforming growth factor beta and interleukin 4 in the prevention of autoimmune thyroiditis in rats by peripheral CD4(+)CD45RC- cells and CD4(+)CD8(-) thymocytes". Journal of Experimental Medicine. 189 (2): 279–88. doi:10.1084/jem.189.2.279. PMC 2192980. PMID 9892610.
  14. ^ Saoudi A, Seddon B, Mason D (1996). "The thymus contains a high frequency of cells that prevent autoimmune diabetes on transfer into prediabetic recipients". Journal of Experimental Medicine. 184 (6): 2393–8. doi:10.1084/jem.184.6.2393. PMC 2196374. PMID 8976193.
  15. ^ Sakaguchi S (2004). "Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses". Annual Review of Immunology. 22: 531–62. doi:10.1146/annurev.immunol.21.120601.141122. PMID 15032588.
  16. ^ Mason, D.W. (2006). Science, Mystical Experience and Religious Belief. York, England: The Ebor Press - William Sessions. ISBN 1-85072-357-5.
  17. ^ Mason, Don. "The Broader View" (PDF). Fusion. University of Oxford. Retrieved 28 July 2016.

Read other articles:

Ibbit-Lim

Ibbit-LimFragmen torso Ibbit-LimRaja EblaBerkuasaskt. 1950 SMInformasi pribadiAyahIgrish-Kheb Ibbit-Lim merupakan penguasa paling awal dari Kerajaan Ketiga Ebla, di Suriah modern, yang memerintah paling mungkin sesaat sebelum 1950 SM.[1] Pemerintahan Ibbit-Lim hanya diketahui oleh fragmen Basal torso yang ditemukan pada tahun 1968 di Tell Mardik dan sekarang di Aleppo, yang merupakan bagian dari patung nazar untuk Inanna, pernah ditempatkan di kuil dewi ini di Akropolis, Ebla.[2&#...

 

 

Castell'Alfero

Castell'AlferoKomuneComune di Castell'AlferoNegara ItaliaWilayahPiedmontProvinsiProvinsi Asti (AT)FrazioniCallianetto, Stazione, Casotto, Serra Perno, Noveiva, Moncucco, Bricco BerettaLuas • Total20,0 km2 (80 sq mi)Ketinggian235 m (771 ft)Populasi (Dec. 2004) • Total2.736 • Kepadatan14/km2 (35/sq mi)DemonimCastellalferesiZona waktuUTC+1 (CET) • Musim panas (DST)UTC+2 (CEST)Kode pos14033Kode area telepon014...

 

 

Angevin Empire

Medieval dynastic union of states in present-day England, France, Ireland, and Wales Angevin EmpireEmpire Plantagenêt[a]1154–1214 Royal banner(first used after 1198) Royal coat of arms The Angevin Empire in 1190StatusComposite monarchy[3]CapitalNo official capital. Court was generally held at Angers and Chinon.Official languagesOld French[4] • Medieval Latin[b]Regional languages Basque Middle Breton Middle Cornish Cumbric Middle English M...

ليونيد كوتشما

ليونيد كوتشما (بالأوكرانية: Леоні́д Дани́лович Ку́чма)‏    معلومات شخصية الميلاد 9 أغسطس 1938 (86 سنة)  الإقامة دنِبرُو  مواطنة الاتحاد السوفيتي أوكرانيا  الزوجة ليودميلا كوتشما  مناصب نائب الشعب الأوكراني   عضو خلال الفترة15 مايو 1990  – 10 مايو 1994  فترة بر�...

 

 

العلاقات الوسط إفريقية الكورية الجنوبية

العلاقات الوسط أفريقية الكورية الجنوبية جمهورية أفريقيا الوسطى كوريا الجنوبية   جمهورية أفريقيا الوسطى   كوريا الجنوبية تعديل مصدري - تعديل   العلاقات الوسط أفريقية الكورية الجنوبية هي العلاقات الثنائية التي تجمع بين جمهورية أفريقيا الوسطى وكوريا الجنوبية.&...

 

 

باب شرقي (دمشق)

الباب الشرقي   تقديم البلد  سوريا مدينة دمشق  إحداثيات 33°30′34″N 36°19′04″E / 33.509444444444°N 36.317777777778°E / 33.509444444444; 36.317777777778  المهندس المعماري سبتيموس سيفيروس [1] تاريخ البناء 200 م تاريخ الافتتاح 200 م المالك محافظة دمشق , مكتب عنبر تصنيف باب أثري الموقع الرسم�...

Under Secretary of Defense for Research and Engineering

Under Secretary of Defense for Research and EngineeringLogo of the Office of the Under Secretary of Defense for Research and EngineeringIncumbentHeidi Shyu[1]since July 25, 2021Office of the Secretary of DefenseReports toSecretary of DefenseDeputy Secretary of DefenseNominatorThe Presidentwith the advice and consent of the SenateTerm lengthNo fixed termWebsiteOffice of the Under Secretary The Under Secretary of Defense for Research and Engineering, abbreviated USD (R&E), is ...

 

 

Économie écologique

Économie écologiqueSchéma de l'économie écologique.Partie de Économiemodifier - modifier le code - modifier Wikidata Les ressources naturelles traversent l'économie et finissent en déchets et en pollution. L’économie écologique est une branche de l'économie en interface avec l'écologie, étudiant l'interdépendance et la coévolution entre les sociétés humaines et les écosystèmes dans le temps et l'espace. L'intérêt de ces recherches est de pouvoir guider l'action des acte...

 

 

Adelheid Morath

German cross-country mountain biker This biography of a living person needs additional citations for verification. Please help by adding reliable sources. Contentious material about living persons that is unsourced or poorly sourced must be removed immediately from the article and its talk page, especially if potentially libelous.Find sources: Adelheid Morath – news · newspapers · books · scholar · JSTOR (August 2012) (Learn how and when to remove this...

Biathlon World Championships 1999

The 34th Biathlon World Championships were held in 1999 in Kontiolahti, Finland.[1] Due to the cold, the individual and the mass start events were moved to Oslo, Norway. The mass start was contested for the first time in the world championships. Medal winners Men Event Gold Silver Bronze 10 km sprintdetails Frank Luck Germany 28:05.6(0+0) Patrick Favre Italy 28:27.6(0+0) Frode Andresen Norway 28:46.4(1+1) 12.5 km pursuitdetails Ricco Groß Germany 35:37.8...

 

 

2017 Indianapolis 500

101st running of the Indianapolis 500 101st Indianapolis 500Indianapolis Motor SpeedwayIndianapolis 500Sanctioning bodyIndyCarSeason2017 IndyCar seasonDateMay 28, 2017Winner Takuma SatoWinning teamAndretti AutosportAverage speed155.395 mph (250.084 km/h)Pole position Scott DixonPole speed232.164 mph (373.632 km/h)Fastest qualifier Scott DixonRookie of the Year Fernando AlonsoMost laps led Max Chilton (50)Pre-race ceremoniesNational anthemBebe Rexha[1]Back Home Again in India...

 

 

Sotto il cielo delle Hawaii (film 2015)

Sotto il cielo delle HawaiiBradley Cooper in una scena del filmTitolo originaleAloha Lingua originaleinglese Paese di produzioneStati Uniti d'America Anno2015 Durata105 min Rapporto1,85:1 Generecommedia, drammatico, sentimentale RegiaCameron Crowe SceneggiaturaCameron Crowe ProduttoreScott Rudin, Cameron Crowe Produttore esecutivoEli Bush, Ilona Herzberg, Ben Waisbren Distribuzione in italiano20th Century Fox FotografiaÉric Gautier MontaggioJoe Hutshing MusicheJón Þór Birgisson Sc...

卡洛斯·梅内姆

此條目需要擴充。 (2015年11月27日)请協助改善这篇條目，更進一步的信息可能會在討論頁或扩充请求中找到。请在擴充條目後將此模板移除。 卡洛斯·梅内姆阿根廷總統府官方照片第47任阿根廷總統任期1989年7月8日—1999年12月10日副总统爱德华多·杜阿尔德卡洛斯·鲁考夫（英语：Carlos Ruckauf）前任劳尔·阿方辛 个人资料出生(1930-07-02)1930年7月2日 阿根廷拉里奥哈省阿尼利亚�...

 

 

Повітряні сили Збройних сил України

Ця стаття потребує додаткових посилань на джерела для поліпшення її перевірності. Будь ласка, допоможіть удосконалити цю статтю, додавши посилання на надійні (авторитетні) джерела. Зверніться на сторінку обговорення за поясненнями та допоможіть виправити недоліки. Мат...

 

 

منتخب المكسيك لهوكي الجليد

منتخب المكسيك الوطني لهوكي الجليد الإتحاد إتحاد المكسيك لهوكي الجليد البلد المكسيك  المدرب دييغو دي لا غارما مساعد المدرب رودريغو غوتيريزلويس أوليفاريس الأكثر لعباً ليور ميلر (46) الأكثر نقاط أدريان سيرفانتيس (52) ألوان الفريق         رمز IIHF MEX التصنيف العالمي لهو...

عصمة بابوية

الروح القدس يحل على البابا غريغوريوس الأول. لوحة للفنان الإيطالي كارلو ساراسيني 1610 العصمة البابوية هي عقيدة كاثوليكية تم إقرارها في المجمع الفاتيكاني الأول عام 1870 في زمن حبرية البابا بيوس التاسع. تقر هذه العقيدة بأن البابا له سلطة شرعية على الكنيسة الكاثوليكية كلها، لذلك ...

 

 

Chicago Daily News

American afternoon daily newspaper This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: Chicago Daily News – news · newspapers · books · scholar · JSTOR (July 2020) (Learn how and when to remove this message) Chicago Daily News1901 adverting posterTypeDaily newspaperFormatBroadsheetOwner(s)Field Enterprises(1959�...

 

 

Царь Никита и сорок его дочерей

Царь Никита и сорок его дочерей Жанр шуточная сказка Автор Пушкин, Александр Сергеевич Язык оригинала русский Дата написания 1822 Дата первой публикации 1858 Текст произведения в Викитеке «Царь Никита и сорок его дочерей» — шуточная (нескромная, срамная) сказка в стихах Але...

Football Club Rieti 2005-2006

Questa voce sull'argomento stagioni delle società calcistiche italiane è solo un abbozzo. Contribuisci a migliorarla secondo le convenzioni di Wikipedia. Segui i suggerimenti del progetto di riferimento. Voce principale: Football Club Rieti. Football Club RietiStagione 2005-2006Sport calcio Squadra Rieti Allenatore Sergio Pirozzi Presidente Stefano Palombi Serie C214º posto nel girone C. Maggiori presenzeCampionato: Bettoni (33) Miglior marcatoreCampionato: Zarineh (5) 2004-2005...

 

 

Adrianus Djajasepoetra

Yang MuliaAdrianus DjajasepoetraS.J.Uskup Agung Emeritus DjakartaGerejaGereja Katolik RomaKeuskupan agungDjakartaPenunjukan18 Februari 1953[1](58 tahun, 343 hari)Masa jabatan berakhir21 Mei 1970 (76 tahun, 70 hari)PendahuluPetrus Johannes WillekensPenerusLeo Soekoto, SJJabatan lainUskup Agung Tituler Volsinium (1970–1976)ImamatTahbisan imam15 Agustus 1928[1](34 tahun, 156 hari)Tahbisan uskup23 April 1953oleh Georges de Jonghe d'Ardoye, M.E....