Domažlice District borders Germany in the west. The terrain is hilly and along the state border, the landscape is mountainous. The territory extends into five geomorphological mesoregions: Upper Palatine Forest (west), Upper Palatine Forest Foothills (north and centre), Plasy Uplands (northeast), Cham-Furth Depression (south) and Švihov Highlands (east). The highest point of the district is the mountain Čerchov in Pec with an elevation of 1,042 m (3,419 ft). The lowest point is the river bed of the Radbuza in Staňkov at 351 m (1,152 ft).
From the total district area of 1,051.8 km2 (406.1 sq mi), agricultural land occupies 564.2 km2 (217.8 sq mi), forests occupy 396.7 km2 (153.2 sq mi), and water area occupies 12.9 km2 (5.0 sq mi). Forests cover 37.7% of the district's area.[1]
The only important river is the Radbuza, which springs in the western part of the district and flows across the district to east. The Chamb also springs here. There are no large bodies of water in the territory. The largest is the Mezholezský Pond with an area of 38 ha (94 acres).[3]
