Middle-aged Samuel Dodsworth is the head of Revelation Motor Company, an automobile manufacturing firm. His wife Fran, a shallow and vain woman obsessed with the notion of growing old, convinces her spouse Sam to sell his interest in the company and take her to Europe. Before long, Fran begins to view herself as a sophisticated world traveler and Sam as boring and unimaginative. Searching for excitement in her life, she begins spending time with other men and eventually informs Sam that she's leaving him for a member of royalty. While in Italy, Sam reunites with Edith Cortright, a widow he first met while en route to Europe via ship, and the two fall in love. Without warning, he breaks off their relationship, then realizes just how much he cares for her.
The cast included Walter Huston as Samuel Dodsworth, Fay Bainter as Fran Dodsworth, Nan Sunderland as Edith Cortright, and Kent Smith as Kurt von Obersdorf.