Dieter Oesterhelt

Dieter Oesterhelt
Born(1940-11-10)10 November 1940
Munich, Gau Munich-Upper Bavaria, Germany
Died28 November 2022(2022-11-28) (aged 82)
Munich, Germany
NationalityGerman
Alma materUniversity of Munich
AwardsLiebig Medal (1983)
Otto Warburg Medal (1991)
Werner von Siemens Ring (1999)
Albert Lasker Award for Basic Medical Research (2021)
Scientific career
InstitutionsUniversity of California, San Francisco
University of Würzburg
Max Planck Society
ThesisZur Kenntnis der Fettsäuresynthetase aus Hefe (1967)
Doctoral advisorFeodor Lynen
Doctoral studentsHartmut Michel
Peter Hegemann
Other notable studentsAxel Brunger (postdoc)
Websitewww.biochem.mpg.de/oesterhelt

Dieter Oesterhelt (10 November 1940 – 28 November 2022)[1] was a German biochemist. From 1980 until 2008, he was director of the Max Planck Institute for Biochemistry, Martinsried.

Biography

Oesterhelt studied chemistry at the University of Munich from 1959 to 1963. From 1964 to 1967 he worked at the Institute of Biochemistry at the same university under Feodor Lynen. He was then a research assistant at the Max Planck Institute for Cell Chemistry until 1969. From 1969 to 1973 he worked as an academic adviser at the Institute for Biochemistry at the University of Munich and carried out work on the structure, function and biosynthesis of the purple membrane of Halobacterium salinarum. In 1975 he became a junior research group leader at the Friedrich Miescher Laboratory in Tübingen. From 1976 to 1979 he was a full professor at the University of Würzburg. Oesterhelt has been a member of the Max Planck Society and director of the Max Planck Institute for Biochemistry, Martinsried, since 1980. He retired in 2008.[2][3]

In 1969, Oesterhelt went to the University of California at San Francisco, where he joined the lab of Walther Stoeckenius to study the cell membrane of Halobacterium salinarum. He proved that retinaldehyde was contained in a protein of the so-called "purple membrane" of Halobacterium. This protein was isolated and called bacteriorhodopsin.[4] After returned to Germany, Oesterhelt showed that physiological function of bacteriorhodopsin is to pump protons out of the cell.[5] Members of his department at the Max Planck Institute for Biochemistry researched the structure-function relationships of membrane proteins and other microbial rhodopsins such as halorhodopsin, which later became a molecular tool in optogenetics. In 2021 he received the Albert Lasker Award for Basic Medical Research.[6]

Oesterhelt died on 28 November 2022, at the age of 82.[7]

Honors and awards

References

  1. ^ Hegemann, Peter; Michel, Hartmut (27 January 2023). "Dieter Oesterhelt (1940–2022)". Science. 379 (6630): 337. Bibcode:2023Sci...379..337H. doi:10.1126/science.adg5458. ISSN 0036-8075. PMID 36701443. S2CID 256275449.
  2. ^ Henning, Eckart (2011). Chronik der Kaiser-Wilhelm-, Max-Planck-Gesellschaft zur Förderung der Wissenschaften 1911 – 2011 ; Daten und Quellen (in German). Berlin: Duncker & Humblot. ISBN 978-3-428-13623-0. OCLC 734081095.
  3. ^ Various articles about Oesterhelt
  4. ^ Oesterhelt, Dieter; Stoeckenius, Walther (September 1971). "Rhodopsin-like Protein from the Purple Membrane of Halobacterium halobium". Nature New Biology. 233 (39): 149–152. doi:10.1038/newbio233149a0. ISSN 2058-1092. PMID 4940442.
  5. ^ Oesterhelt, D.; Stoeckenius, W. (1 October 1973). "Functions of a New Photoreceptor Membrane". Proceedings of the National Academy of Sciences. 70 (10): 2853–2857. Bibcode:1973PNAS...70.2853O. doi:10.1073/pnas.70.10.2853. ISSN 0027-8424. PMC 427124. PMID 4517939.
  6. ^ Lasker Awards.
  7. ^ "Prof. Dr. Dieter Oesterhelt († 28. November 2022)". MPG. Retrieved 30 November 2022.

Further reading