Dennis S. Charney is an American biological psychiatrist and researcher, with expertise in the neurobiology and treatment of mood and anxiety disorders.[1] He is the author of Neurobiology of Mental Illness, The Physician's Guide to Depression and Bipolar Disorders and Molecular Biology for the Clinician, as well as the author of over 600 original papers and chapters. In 2022, he was listed #49 on Research.com's "Top Medicine Scientists in the United States," with an h-index of 218 with 173,960 citations across 887 publications.[2][3] Charney is known for demonstrating that ketamine is effective for treating depression. Ketamine's use as a rapidly-acting anti-depressant is recognized as a breakthrough treatment in mental illness.[4][5]
In 2007, he became the Dean of the School and Executive Vice President for Academic Affairs of what was then known as the Mount Sinai Medical Center. In 2013, he was named President of Academic Affairs for the Mount Sinai Health System and as of 2024 still holds these roles.[6]
With Steven Southwick, MD, Professor of Psychiatry at Yale University, Charney authored Resilience: The Science of Mastering Life's Greatest Challenges, which reflects on the science of resilience and identifies ten factors that contribute to highly reliant people.[7] With Eric J. Nestler, MD, he is author of Charney & Nestler's Neurobiology of Mental Illness, which went into its fifth edition in 2018.[8]
Biography
Education and career
Charney graduated from medical school at Penn State in 1977 and completed his residency in Psychiatry at Yale School of Medicine. A fellowship in Biological Psychiatry was completed at the Connecticut Medical Health Center.
Neuron published that Charney's neurobiological insights into ketamine are a novel approach to the underlying operation of mechanism-of-action for rapid-acting antidepressant efficacy and mood disorders[12] and is the first model of a rapid-acting antidepressant with efficacy for treatment-resistant symptoms of mood disorders. His intranasal ketamine treatment was approved by the FDA in 2019 and now produced under the brand name Spravato.[13]Scientific American published in 2018 that the development is the first new form of antidepressant since the 1950s.[14]
General
General psychiatry research includes work on anxiety, mood and psychopathology linked to work in injury prevention,[15] thereby connecting myriad disciplines of study. Research into depression shows elements of internal medicine and management. Clinical psychology includes psychological intervention and resilience. Research shows themes of randomized controlled trials and Esketamine.[16]Traumatic stress, anxiety and neuroscience[17] is part of his psychology study and is frequently connected to suicide prevention, bridging the gap between various science disciplines and establishing new relationships. Other areas of study are bipolar disorder, endocrinology and oncology.
Charney's research on digital mental health research contributed to the development of Rejoyn, the first FDA-approved prescription digital therapeutic for major depressive disorder (MDD). The treatment is designed to be used alongside standard care and medication to help reduce MDD symptoms.[18][19][20][21]
2014–2015 Distinguished Alumni Award, Pennsylvania State University[4]
Personal life
Charney is the father of five children and grandfather of eight. On the morning of August 29, 2016, Charney was shot and wounded by Hengjun Chao, as Charney left Lange's Deli in Charney's hometown of Chappaqua,[44] New York. Chao was a former Mount Sinai medical researcher who had been fired by Charney in 2010 for research fraud.[45][46][47] Chao's trial began on June 5, 2017, and eight days later Chao was convicted of attempted second-degree murder and two other charges in Westchester County Court in White Plains. He was sentenced to 28 years in prison.[48][49][50][51][52] These personal events contributed first-hand to his study of resilience and are discussed in this his book "Resilience".[7][53]
2023 Charney DS, Southwick DM, DePierro JM, Resilience: The Science of Mastering Life's Greatest Challenges Cambridge University Press; Third Edition, ISBN978-1-009-29974-9
2018 Charney DS, Nestler EJ, Charney & Nestler's Neurobiology of Mental Illness, Oxford University Press; Fifth Edition, ISBN978-0-19-068142-5
2018 Charney DS, Southwick SM, Resilience: The Science of Mastering Life's Greatest Challenges, Cambridge University Press, Second Edition, ISBN978-1-108-44166-7
2013 Charney DS, Nestler EJ, Buxbaum JD, Sklar Pamela (eds). Neurobiology of Mental Illness, New York, NY, Oxford University Press, Fourth Edition ISBN0-19-939846-1
2011 Southwick SM, Litz BT, Charney DS, Friedman MJ Resilience and Mental Health: Challenges Across the Lifespan, Cambridge University Press ISBN0-521-89839-0
2012 Charney DS, Southwick SM Resilience: The Science of Mastering Life's Greatest Challenges, Cambridge University Press ISBN0-521-19563-2
2009 Stress-induced and Fear Circuitry Disorders: Refining the Research Agenda for Dsm-v by Gavin Andrews, Dennis S. Charney, Paul J. Sirovatka, Darrel A. Regier, American Psychiatric Publishing, ISBN0-89042-344-X
2006 The Physician's Guide to Depression & Bipolar Disorders by Dennis S. Charney, Lydia Lewis, McGraw-Hill, ISBN0-07-144175-1 (0-07-144175-1)
2003 Molecular Biology for the Clinician, by Dennis S. Charney, American Psychiatric Press, ISBN978-1-58562-113-2
2002 Pediatric Psychoparmacology: Principles and Practice by James F. Leckman, Dennis S. Charney, Lawrence Scahill, Andres Martin, Oxford Univ Pr, ISBN0-19-514173-3 (0-19-514173-3)
2002 Neuropsychopharmacology: The Fifth Generation of Progress by American College of Neuropsychopharmacology and Joseph T. Coyle and Charles Nemeroff and Dennis Charney and Kenneth L. Davis, Hardcover, Lippincott Williams & Wilkins, ISBN0-7817-2837-1 (0-7817-2837-1)
1995 Neurobiological and Clinical Consequences of Stress: From Normal Adaptation to Post-Traumatic Stress Disorder by Matthew J. Friedman, Dennis S. Charney, Ariel Y. Deutch, Lippincott Williams & Wilkins, ISBN0-7817-0177-5 (0-7817-0177-5)
Goodman WK, Price LH, Rasmussen SA, et al. The Yale-Brown Obsessive Compulsive Scale: I. Development, Use, and Reliability.[57] Arch Gen Psychiatry. 1989;46(11):1006–1011. doi:10.1001/archpsyc.1989.01810110048007 PMID2684084 (9607 citations)
Blake DD, Weathers FW, Nagy LM, Kaloupek DG, Gusman FD, Charney DS, Keane TM. The development of a Clinician-Administered PTSD Scale. J Trauma Stress.[58] 1995 Jan;8(1):75-90. doi: 10.1007/BF02105408. PMID7712061. (6352 citations)
Krystal JH, Karper LP, Seibyl JP, Freeman GK, Delaney R, Bremner JD, Heninger GR, Bowers MB Jr, Charney DS. Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses. Arch Gen Psychiatry. 1994 Mar;51(3):199-214. doi: 10.1001/archpsyc.1994.03950030035004.[59]PMID8122957. (4108 citations)
Other notable articles:
Berman RM, Cappiello A, Anand A, Oren DA, Heninger GR, Charney DS, Krystal JH: Antidepressant Effects of Ketamine in Depressed Patients. Biological Psychiatry, 2000; 47:351-354.[60]
Charney DS: Psychobiological Mechanisms of resilience and vulnerability: Implications for the successful adaptation to extreme stress. Am J Psychiatry, 2004; 161:195-216.[61]
Zarate CA Jr, Singh JB, Carlson PJ, Brutsche NE, Ameli R, Luckenbaugh DA, Charney DS, Manji HK. A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression. Arch Gen Psychiatry. 2006 Aug;63(8):856-64. doi: 10.1001/archpsyc.63.8.856. PMID16894061
Murrough JW, Iosifescu DV, Chang LC, Al Jurdi RK, Green CE, Perez AM, Iqbal S, Pillemer S, Foulkes A, Shah A, Charney DS, Mathew SJ. Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial. Am J Psychiatry. 2013 Oct 1;170(10):1134-42.[62]
Feder A, Parides MK, Murrough JW, Perez AM, Morgan JE, Saxena S, Kirkwood K, Aan Het Rot M, Lapidus KA, Wan LB, Iosifescu D, Charney DS. Efficacy of Intravenous Ketamine for Treatment of Chronic Posttraumatic Stress Disorder: A Randomized Clinical Trial. JAMA Psychiatry. 2014 Jun;71(6):681-8.[63]
Iacoviello BM, Wu G, Alvarez E, Huryk K, Collins KA, Murrough JW, Iosifescu DV, Charney DS. Cognitive-Emotional Training as an Intervention for Major Depressive Disorder. Depress Anxiety. 2014 Aug;31(8):699-706.[64]
Feder A, Fred-Torres S, Southwick SM, Charney DS. The Biology of Human Resilience: Opportunities for Enhancing Resilience Across the Life Span. Biol Psychiatry. 2019 Sep 15;86(6):443-453.[65]
Krystal JH, Charney DS, Duman RS. A New Rapid-Acting Antidepressant. Cell. 2020 Apr 2;181(1):7.[66]
Charney AW, Katz C, Southwick SM, Charney DS. A Call to Protect the Health Care Workers Fighting COVID-19 in the United States. Am J Psychiatry. 2020 Jul 31.[67]
Feder A, Costi S, Rutter SB, Collins AB, Govindarajulu U, Jha MK, Horn SR, Kautz M, Corniquel M, Collins KA, Bevilacqua L, Glasgow AM, Brallier J, Pietrzak RH, Murrough JW, Charney DS. A Randomized Controlled Trial of Repeated Ketamine Administration for Chronic Posttraumatic Stress Disorder. Am J Psychiatry. 2021 Feb 1;178(2).[68]
^Goodman, Wayne K.; Price, Lawrence H.; Rasmussen, Steven A.; Mazure, Carolyn; Fleischmann, Roberta L.; Hill, Candy L.; Heninger, George R.; Charney, Dennis S. (1989-11-01). "The Yale-Brown Obsessive Compulsive Scale: I. Development, Use, and Reliability". Archives of General Psychiatry. 46 (11): 1006–1011. doi:10.1001/archpsyc.1989.01810110048007. ISSN0003-990X. PMID2684084.
^Krystal, John H.; Karper, Laurence P.; Seibyl, John P.; Freeman, Glenna K.; Delaney, Richard; Bremner, J. Douglas; Heninger, George R.; Bowers, Malcolm B. Jr; Charney, Dennis S. (1994-03-01). "Subanesthetic Effects of the Noncompetitive NMDA Antagonist, Ketamine, in Humans: Psychotomimetic, Perceptual, Cognitive, and Neuroendocrine Responses". Archives of General Psychiatry. 51 (3): 199–214. doi:10.1001/archpsyc.1994.03950030035004. ISSN0003-990X. PMID8122957.
^Berman, R. M.; Cappiello, A.; Anand, A.; Oren, D. A.; Heninger, G. R.; Charney, D. S.; Krystal, J. H. (2000-02-15). "Antidepressant effects of ketamine in depressed patients". Biological Psychiatry. 47 (4): 351–354. doi:10.1016/s0006-3223(99)00230-9. ISSN0006-3223. PMID10686270. S2CID43438286.
^Feder, Adriana; Parides, Michael K.; Murrough, James W.; Perez, Andrew M.; Morgan, Julia E.; Saxena, Shireen; Kirkwood, Katherine; Aan Het Rot, Marije; Lapidus, Kyle A. B.; Wan, Le-Ben; Iosifescu, Dan (2014). "Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial". JAMA Psychiatry. 71 (6): 681–688. doi:10.1001/jamapsychiatry.2014.62. ISSN2168-6238. PMID24740528.
^Iacoviello, Brian M.; Wu, Gang; Alvarez, Evan; Huryk, Kathryn; Collins, Katherine A.; Murrough, James W.; Iosifescu, Dan V.; Charney, Dennis S. (2014). "Cognitive-emotional training as an intervention for major depressive disorder". Depression and Anxiety. 31 (8): 699–706. doi:10.1002/da.22266. ISSN1520-6394. PMID24753225. S2CID205736356.
^Feder, Adriana; Fred-Torres, Sharely; Southwick, Steven M.; Charney, Dennis S. (2019-09-15). "The Biology of Human Resilience: Opportunities for Enhancing Resilience Across the Life Span". Biological Psychiatry. 86 (6): 443–453. doi:10.1016/j.biopsych.2019.07.012. ISSN1873-2402. PMID31466561. S2CID199544779.
^Charney, Alexander W.; Katz, Craig; Southwick, Steven M.; Charney, Dennis S. (2020-10-01). "A Call to Protect the Health Care Workers Fighting COVID-19 in the United States". The American Journal of Psychiatry. 177 (10): 900–901. doi:10.1176/appi.ajp.2020.20040535. ISSN1535-7228. PMID32731814. S2CID220893056.
^Feder, Adriana; Costi, Sara; Rutter, Sarah B.; Collins, Abigail B.; Govindarajulu, Usha; Jha, Manish K.; Horn, Sarah R.; Kautz, Marin; Corniquel, Morgan; Collins, Katherine A.; Bevilacqua, Laura (2021-02-01). "A Randomized Controlled Trial of Repeated Ketamine Administration for Chronic Posttraumatic Stress Disorder". The American Journal of Psychiatry. 178 (2): 193–202. doi:10.1176/appi.ajp.2020.20050596. ISSN1535-7228. PMID33397139. S2CID230658032.
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