Delta State competes in 15 intercollegiate varsity sports. Men's sports include baseball, basketball, cheerleading, football, golf, soccer, swimming and diving, and tennis; while women's sports include basketball, cheerleading, cross country, soccer, softball, swimming and diving, and tennis.
The Lady Statesman began play in 1925. They are the only Division II team with 1,000 wins. They play in the Gulf South Conference. Delta State plays their home games at Walter Sillers Coliseum. They have made the NCAA Tournament 27 times, with a record of 57–25. They are coached by Craig Roden. Margaret Wade coached them to three AIAW National titles, while Lloyd Clark coached them to three Division II titles.[5][6]