Deiodinase

Iodothyronine deiodinases catalyze release of iodine directly from the thyronine hormones. They are selenocysteine-dependent membrane proteins with a catalytic domain resembling peroxiredoxins (Prx).^[1] Three related isoforms, deiodinase type I, II, and III, contribute to activation and inactivation of the initially released hormone precursor T₄ (thyroxine) into T₃ (triiodothyronine) or rT₃ (reverse triiodothyronine) in target cells. The enzymes catalyze a reductive elimination of iodine (the different isoforms attack different thyronine positions), thereby oxidizing themselves similar to Prx, followed by a reductive recycling of the enzyme.

Iodotyrosine deiodinase contributes to breakdown of thyroid hormones. It releases iodine, for renewed use, from iodinated tyrosines resulting from catabolism of iodothyronines. Iodotyrosine deiodinase employs a flavin mononucleotide cofactor and belongs to the NADH oxidase/flavin reductase superfamily.^[2]

Starvation response

In starvation or severe somatic stress, deiodinase type 1 is inhibited which lowers circulating levels of T₃ (due to it being the main source of peripherally converted T₃ from T₄ in the plasma), causing a decrease in the metabolic rate.^[3] Intuitively, if plasma levels of T₃ fall, there would be a compensatory rise in TSH, the secretion of which is inhibited by T₃. However, because type 2 deiodinase mediates the conversion of T₄ to T₃ within the pituitary and CNS, and because caloric restriction does not affect this enzyme, local T₃ levels in the pituitary are normal. Thus, the thyrotrophs (endocrine cells in pituitary) in the pituitary continue to have adequate amounts of T₃, and no compensatory rise in TSH occurs. This effect of caloric restriction makes sense for someone who is starving because it tends to conserve body stores of fuel. On the other hand, this effect makes it more difficult to lose weight intentionally while dieting.

Selenium

Selenium in iodothyronine deiodinase, as selenocysteine, plays a crucial role in determining the free circulating levels of T₃. Selenium deficiency can have implications in fall of T₃ levels.

References

^ Schweizer U, Schlicker C, Braun D, Köhrle J, Steegborn C (July 2014). "Crystal structure of mammalian selenocysteine-dependent iodothyronine deiodinase suggests a peroxiredoxin-like catalytic mechanism". Proceedings of the National Academy of Sciences of the United States of America. 111 (29): 10526–31. Bibcode:2014PNAS..11110526S. doi:10.1073/pnas.1323873111. PMC 4115520. PMID 25002520.
^ Thomas SR, McTamney PM, Adler JM, Laronde-Leblanc N, Rokita SE (July 2009). "Crystal structure of iodotyrosine deiodinase, a novel flavoprotein responsible for iodide salvage in thyroid glands". The Journal of Biological Chemistry. 284 (29): 19659–67. doi:10.1074/jbc.M109.013458. PMC 2740591. PMID 19436071.
^ Chatzitomaris, A; Hoermann, R; Midgley, JE; Hering, S; Urban, A; Dietrich, B; Abood, A; Klein, HH; Dietrich, JW (2017). "Thyroid Allostasis-Adaptive Responses of Thyrotropic Feedback Control to Conditions of Strain, Stress, and Developmental Programming". Frontiers in Endocrinology. 8: 163. doi:10.3389/fendo.2017.00163. PMC 5517413. PMID 28775711.

External links

Deiodinase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

v t e Oxidoreductases: peroxidases (EC 1.11)
1.11.1.1-14	NADH peroxidase NADPH peroxidase Fatty-acid peroxidase Catalase Cytochrome c peroxidase Eosinophil peroxidase Glutathione peroxidase GPX 1 2 3 4 5 6 7 8 Horseradish peroxidase Lactoperoxidase Myeloperoxidase Thyroid peroxidase Deiodinase Iodothyronine deiodinase Iodotyrosine deiodinase
1.11.1.15 (peroxiredoxin)	1 2 3 4 5 6

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