The school originally opened in 1955. In 2005 local voters passed Measure J, a bond measure which included $161 million to completely rebuild the De Anza campus. Reconstruction began in 2009 with a new all-weather track and artificial-turf football field, along with the demolition of the gym and other site preparation work. The new facility was opened for the start of the 2013 - 2014 school year.
The school offers four specialized course tracks intended to prepare students for a specific career, known as academies. The academies offered are health, information technology, law and JROTC. There are also many student-run clubs at De Anza, which range from clubs founded based around a shared interest like anime to clubs intended to support minority populations at the school.