David Siderovski

David Siderovski
Education
AwardsASPET's John J. Abel Award in 2004
Scientific career
FieldsBiochemistry
Pharmacology
Neuroscience
Medical education
InstitutionsAmgen Research Institute
University of North Carolina at Chapel Hill
West Virginia University
University of North Texas Health Science Center
ThesisHuman Immunodeficiency Virus Type-1 Trans-activator of Transcription (HIV-1 Tat) (1997)
Doctoral advisorTak Wah Mak
Other academic advisorsAlfred G. Gilman
Robert J. Lefkowitz

David Siderovski is a North American pharmacologist.[1] Since March 2020, Siderovski has been Chair of the HSC Department of Pharmacology & Neuroscience at the University of North Texas Health Science Center.[2] From 2012 to 2019, he was the E.J. Van Liere Medicine Professor and Chair of Physiology, Pharmacology & Neuroscience for the West Virginia University School of Medicine.[3]

Education

Siderovski attended Earl Haig Secondary School in North York, Ontario,[4] graduating in 1985.[5] In 1989, Siderovski graduated with a BSc from Queen's University in Kingston, Ontario.[6]

Siderovski began his PhD training at the University of Toronto in May 1989. During his fifth year of his PhD, he began full-time work as a research scientist in the Quantitative Biology Laboratory of the Amgen Research Institute, Toronto.[7] He successfully defended his PhD thesis in November 1997.[8] He left the Amgen Research Institute in December 1998, having contributed to three patents as a co-inventor.[9][10][11]

Career

After completing his industrial postdoctoral position at the Amgen Research Institute in 1998,[7] Siderovski joined the faculty at the University of North Carolina at Chapel Hill as an assistant professor of pharmacology.[12] His earliest publications discuss the RGS protein superfamily,[13][14][15][16] and determinations of their varied protein structures[17][18][19] and cellular functions.[20][better source needed]

In 2004, Siderovski was named the top American Pharmacologist under 40 and awarded the John J. Abel Award by the American Society for Pharmacology and Experimental Therapeutics.[21][22][better source needed]

From 2006 to 2012, Siderovski was the Thomas J. Dark Basic Science Director of UNC's Medical Scientist Training Program.[23] In August 2014, Siderovski was appointed Director of the West Virginia University School of Medicine MD/PhD Scholars Program.[24] Siderovski has been serving as Editorial Board Member for the Journal of Biological Chemistry since 2012.[25]

References

  1. ^ "Abel Numbers" (PDF). ASPET.org. May 30, 2019. Retrieved November 21, 2019.
  2. ^ Joy, William (12 March 2020). "New COVID-19 treatment has helped dozens in China, UNTHSC researchers say". wfaa.com. WFAA (ABC Channel 8 Dallas, TX).
  3. ^ Mcmurtrie, Beth (2017-10-01). "One University Takes On the Opioid Crisis". The Chronicle of Higher Education. ISSN 0009-5982. Retrieved 2019-11-21.
  4. ^ Gotlieb, Risha (9 Sep 1993). "School caters to bright kids". The Toronto Star. No. Page NY5. Torstar Syndication Services, a Division of Toronto Star Newspapers Limited. Retrieved 27 December 2021.
  5. ^ Little, James (5 July 1985). "Two students who had 98.5 averages are both dubbed Metro's top students". The Toronto Star. Torstar Syndication Services, a Division of Toronto Star Newspapers Limited. ProQuest 1400913014. Retrieved 27 December 2021.
  6. ^ "Prince of Wales Prizes". Automatic Awards Open to All Upper Year Students. Queen's University. Archived from the original on 24 September 2015. Retrieved 11 August 2015.
  7. ^ a b "Can You Go Home Again? | The Scientist Magazine". The Scientist. Retrieved 2016-06-09.
  8. ^ Siderovski, David Peter (1997). Human immunodeficiency virus type-1 trans-activator of transcription (HIV-1 Tat): Random mutagenesis and interaction with PKR (PDF). University of Toronto. Retrieved 2015-08-04.
  9. ^ "Methods of modulating T-cell activation WO 1997041438 A1". Retrieved 9 August 2015.
  10. ^ "Apoptosis-inducing factor CA 2352467 A1". Retrieved 9 August 2015.
  11. ^ "Apoptosis-inducing factor CA 2352467 C". Retrieved 9 August 2015.
  12. ^ Lang, Leslie (25 March 2004). "UNC's Siderovski wins pharmacology award". EurekAlert!. Retrieved 28 December 2021.
  13. ^ Roush, Wade (23 February 1996). "Regulating G Protein Signaling". Science. 271 (5252): 1056–1058. Bibcode:1996Sci...271.1056R. doi:10.1126/science.271.5252.1056. PMID 8599078. S2CID 83216123.
  14. ^ Snow BE, Antonio L, Suggs S, Gutstein HB, Siderovski DP (April 1997). "Molecular cloning and expression analysis of rat Rgs12 and Rgs14". Biochem Biophys Res Commun. 233 (3): 770–7. doi:10.1006/bbrc.1997.6537. PMID 9168931.
  15. ^ Snow BE, Antonio L, Suggs S, Siderovski DP (January 1998). "Cloning of a retinally abundant regulator of G-protein signaling (RGS-r/RGS16): genomic structure and chromosomal localization of the human gene". Gene. 206 (2): 247–53. doi:10.1016/s0378-1119(97)00593-3. PMID 9469939.
  16. ^ Siderovski DP, Strockbine B, Behe CI (1999). "Whither goest the RGS proteins?". Crit Rev Biochem Mol Biol. 34 (4): 215–51. doi:10.1080/10409239991209273. PMID 10517644.
  17. ^ Davis, Molly (1 May 2007). "Picture-perfect Proteins". Endeavors.
  18. ^ Snow BE, Hall RA, Krumins AM, Brothers GM, Bouchard D, Brothers CA, Chung S, Mangion J, Gilman AG, Lefkowitz RJ, Siderovski DP (July 1998). "GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain". J Biol Chem. 273 (28): 17749–55. doi:10.1074/jbc.273.28.17749. PMID 9651375.
  19. ^ Snow BE, Krumins AM, Brothers GM, Lee SF, Wall MA, Chung S, Mangion J, Arya S, Gilman AG, Siderovski DP (October 1998). "A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits". Proceedings of the National Academy of Sciences of the United States of America. 95 (22): 13307–12. Bibcode:1998PNAS...9513307S. doi:10.1073/pnas.95.22.13307. PMC 23793. PMID 9789084.
  20. ^ Ingi T, Krumins AM, Chidiac P, Brothers GM, Chung S, Snow BE, Barnes CA, Lanahan AA, Siderovski DP, et al. (September 1998). "Dynamic regulation of RGS2 suggests a novel mechanism in G-protein signaling and neuronal plasticity". J Neurosci. 18 (18): 7178–88. doi:10.1523/JNEUROSCI.18-18-07178.1998. PMC 6793237. PMID 9736641.
  21. ^ "ASPET AWARD WINNERS FOR 2004" (PDF). The Pharmacologist. 46 (1): 3. March 2004. Retrieved 27 December 2021.
  22. ^ Lang, Leslie (25 March 2004). "UNC's Siderovski wins pharmacology award". EurekAlert!. Retrieved 28 December 2021.
  23. ^ "Leadership". UNC MD-PhD Program (circa March 24, 2012). Internet Archive Wayback Machine. Archived from the original on March 24, 2012. Retrieved 12 August 2015.
  24. ^ "Siderovski Chosen to Oversee M.D./PH.D. Scholars Program". School of Medicine > Home > News > Story. WVU School of Medicine. 11 August 2014. Retrieved 13 August 2015.
  25. ^ "JBC Editorial Board".