He danced in the Yiddish Theatre from 1960 to 1964. He danced in the CBS Productions of And David Wept (choreography by José Limón), Dreams (choreography by Anna Sokolow), Lamp Unto My Feet, and Camera Three, along with many PBS and WNET (NYC) programs.
Lewis joined the dance faculty of the Juilliard School in 1967, and was assistant to the school's Director of Dance, Martha Hill, between 1984 and 1987. He also served as an adjunct professor at New York University and a professor at Amherst College for six years. In 1987, Lewis joined the New World School of the Arts of the Miami Dade College as founding Dean of the Dance Department. Lewis established the dance division's eight-year Bachelor of Fine Arts (BFA) program. In 1988, he formed Miami Dance Futures, Inc., a production company for the Miami Balanchine Conference, the Dance History Scholars’ Conference, the National High School Dance Festival and the Daniel Lewis Dance Sampler.