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DPM3
Identifiers
Aliases	DPM3, CDG1O, dolichyl-phosphate mannosyltransferase subunit 3, dolichyl-phosphate mannosyltransferase subunit 3, regulatory, MDDGB15, MDDGC15
External IDs	OMIM: 605951; MGI: 1915813; HomoloGene: 17810; GeneCards: DPM3; OMA:DPM3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	155,140,595 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	89,174,386 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; anterior pituitary; ; left adrenal cortex; ; right adrenal gland; ; right uterine tube; ; right adrenal cortex; ; monocyte; ; body of pancreas; ; canal of the cervix; ; right lobe of liver;
	Top expressed in
	intestinal villus; ; blastocyst; ; Ileal epithelium; ; choroid plexus of fourth ventricle; ; yolk sac; ; lip; ; right kidney; ; esophagus; ; lactiferous gland; ; ventricular zone;
	More reference expression data
	n/a
Gene ontology
Molecular function	dolichyl-phosphate beta-D-mannosyltransferase activity; protein binding;
Cellular component	integral component of membrane; dolichol-phosphate-mannose synthase complex; integral component of endoplasmic reticulum membrane; mannosyltransferase complex; endoplasmic reticulum membrane; endoplasmic reticulum; membrane;
Biological process	protein glycosylation; GPI anchor biosynthetic process; protein mannosylation; protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan; regulation of protein stability; protein O-linked mannosylation; protein N-linked glycosylation via asparagine; carbohydrate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	54344
	68563
	ENSG00000179085
	ENSMUSG00000042737
	Q9P2X0; Q86TM7
	Q9D1Q4
	NM_153741; NM_018973
	NM_026767
	NP_061846; NP_714963; NP_714963.1
	NP_081043
	Wikidata
View/Edit Human	View/Edit Mouse

dolichyl-phosphate mannosyltransferase polypeptide 3, also known as DPM3, is a human gene.^[5]^[6]

Function

Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a subunit of dolichyl-phosphate mannosyltransferase and acts as a stabilizer subunit of the dolichyl-phosphate mannosyltransferase complex.^[5]