Cytochrome b5 deficiency

Cytochrome b5 deficiency
SpecialtyEndocrinology

Cytochrome b5 deficiency is a rare condition and form of isolated 17,20-lyase deficiency caused by deficiency in cytochrome b5, a small hemoprotein that acts as an allosteric factor to facilitate the interaction of CYP17A1 (17α-hydroxylase/17,20-lyase) with P450 oxidoreductase (POR), thereby allowing for the 17,20-lyase activity of CYP17A1.[1][2][3] The condition affects both adrenal and gonadal androgen biosynthesis and results in male pseudohermaphroditism.[1] The principal biological role of cytochrome b5 is reduction of methemoglobin, so cytochrome b5 deficiency can also result in elevated methemoglobin levels and/or methemoglobinemia, similarly to deficiency of cytochrome b5 reductase (methemoglobin reductase).[1]

References

  1. ^ a b c Mark A. Sperling (10 April 2014). Pediatric Endocrinology E-Book. Elsevier Health Sciences. pp. 498–. ISBN 978-1-4557-5973-6.
  2. ^ Mansouri A, Lurie AA (January 1993). "Concise review: methemoglobinemia". Am. J. Hematol. 42 (1): 7–12. doi:10.1002/ajh.2830420104. PMID 8416301. S2CID 221426714.
  3. ^ "Congenital methemoglobinemia with cytochrome b5 deficiency". N. Engl. J. Med. 315 (14): 893–4. October 1986. doi:10.1056/NEJM198610023151415. PMID 3748110.
Stub icon

This article about an endocrine, nutritional, or metabolic disease is a stub. You can help Wikipedia by expanding it.

Read other articles:

Anna Maslovskaya

Anna Ivanova MaslovskayaNama asalАнна Ивановна МасловскаяLahir6 Januari 1920Distrik Pastavy, Wilayah Vitebsk, Uni SovietMeninggal11 November 1980Moskwa, Uni SovietKebangsaan Uni Soviet Anna Maslovskaya (bahasa Rusia: Анна Масловская; 6 Januari 1920 – 11 November 1980) adalah seorang partisan Soviet di Republik Sosialis Soviet Belarusia pada masa pendudukan Jerman pada Perang Dunia Kedua. Ia dianugerahi gelar Pahlawan Uni Sovie...

 

Nilangsuka

Nilangsuka Perangko India dengan tepian berwarna NilangsukaCommon connotationsKetenteraman     Koordinat warnaTriplet hex#008B8BCMYKH   (c, m, y, k)(100, 0, 0, 45)SumberDaftar Istilah Warna[1]ColorHexa[2]H: Dinormalkan ke [0–100] (ratusan) Nilangsuka atau Benhur tua (Inggris: Dark cyancode: en is deprecated ) adalah suatu corak warna tua pertengahan hijau dan biru. Warna ini adalah salah-satu warna peramban.[3] Rujukan ^ Adiwimarta, Sri Sukesi...

 

Deinze

DeinzeKota dan municipalityClockwise from top: Marketplace, Onze-Lieve-Vrouwekerk, Old City Hall, Ooidonk Castle BenderaLambang kebesaranLocation of Deinze DeinzeLokasi di Belgia Location of Deinze in East Flanders Koordinat: 50°59′N 03°32′E / 50.983°N 3.533°E / 50.983; 3.533Koordinat: 50°59′N 03°32′E / 50.983°N 3.533°E / 50.983; 3.533Negara BelgiaMasyarakatMasyarakat FlandriaDaerahDaerah FlandriaProvinsiFlandria TimurArron...

سفارة آيسلندا في كندا

سفارة آيسلندا في كندا آيسلندا كندا الإحداثيات 45°25′07″N 75°42′12″W / 45.4185°N 75.7034°W / 45.4185; -75.7034 البلد كندا  المكان أوتاوا العنوان Constitution Square, Ottawa [الإنجليزية]‏ الاختصاص كندا،  وكوستاريكا[1]،  وهندوراس[1]،  وبنما[1]،  وفنزويلا[1]،  وت�...

 

Meadow Branch

River in West Virginia, United StatesMeadow BranchMeadow Branch within Sleepy Creek Wildlife Management Area, downstream of the Sleepy Creek Lake impoundment, August 2016.Location of the mouth of Meadow Branch in West VirginiaShow map of West VirginiaMeadow Branch (the United States)Show map of the United StatesLocationCountryUnited StatesStateWest VirginiaCountiesBerkeley, MorganPhysical characteristicsSource  • locationWest of Shanghai, Berkeley County •...

 

Tsinghua Shenzhen International Graduate School

University in Shenzhen, Guangdong, China Tsinghua Shenzhen International Graduate School清华大学深圳国际研究生院Former nameGraduate School at Shenzhen (GSST)Motto自强不息、厚德载物[1]Motto in EnglishSelf-Discipline and Social Commitment[2]TypePublicEstablished2011; 13 years ago (2011)PresidentYang Bin[3]LocationShenzhen, ChinaFlowerRedbud and Lilac[4]Colors  Purple  White[5][6]AffiliationsC9A...

Anton Ferdinand

English association football player Anton Ferdinand Ferdinand playing for Sunderland in 2011Personal informationFull name Anton Julian Ferdinand[1]Date of birth (1985-02-18) 18 February 1985 (age 39)[2]Place of birth Peckham, EnglandHeight 6 ft 0 in (1.83 m)[3]Position(s) Centre back[4]Youth career1994–2003 West Ham UnitedSenior career*Years Team Apps (Gls)2003–2008 West Ham United 138 (5)2008–2011 Sunderland 85 (0)2011–2013 Queens P...

 

Task Force 74

United States Navy task force deployed to the Bay of Bengal during the 1971 India–Pakistan War Task Force 74 was a naval task force that has existed twice. The first Task Force 74 was a mixed Allied force of Royal Navy, Royal Australian Navy, and United States Navy ships which operated against Japanese forces from 1943 to 1945 during the Pacific campaign. The second Task Force 74 was assembled from the U.S. Navy's Seventh Fleet that was deployed to the Bay of Bengal by the Nixon administrat...

 

Cagliari Calcio 1975-1976

Voce principale: Cagliari Calcio. Cagliari CalcioStagione 1975-1976La squadra all'esordio in campionato Sport calcio Squadra Cagliari Allenatore Luis Suárez, poi Mario Tiddia Presidente Andrea Arrica Serie A16º (retrocesso in Serie B) Coppa ItaliaPrimo turno Maggiori presenzeCampionato: Viola (28)Totale: Viola (32) Miglior marcatoreCampionato: Riva, Virdis (6)Totale: Riva, Virdis (6) StadioSant'Elia Abbonati11 629[1] Maggior numero di spettatori40 367 Media spettator...

Jalur kereta api Tarik–Sidoarjo

Jalur kereta api Tarik-SidoarjoIkhtisarJenisJalur lintas utamaSistemJalur kereta api rel beratStatusBeroperasiTerminusTarikSidoarjoStasiun4OperasiDibuka16 Oktober 1880Ditutup1972-1973Dibuka kembali12 November 2014PemilikDirektorat Jenderal PerkeretaapianOperatorPT Kereta Api Indonesia Daerah Operasi VIII Surabaya Stasiun Sidoarjo KAI Commuter Karakteristik lintasRel lintas datarData teknisLebar sepur1.067 mmKecepatan operasi80 km/jam Peta rute Legenda KTS–WO ke Kertosono TRK Tarik J D...

 

Sonetti (Shakespeare)

SonettiFrontespizio dei Sonetti AutoreWilliam Shakespeare 1ª ed. originale1609 Genereraccolta di sonetti Lingua originaleinglese Modifica dati su Wikidata · Manuale I Sonetti (Shakespeare's Sonnets) è il titolo di una collezione di 154 sonetti di William Shakespeare, che spaziano dai temi come lo scorrere del tempo, l'amore, alla bellezza, alla caducità e alla mortalità. I primi 126 sono indirizzati a un uomo, gli ultimi 28 a una donna. L'opera fu pubblicata da Thomas Thorpe in un i...

 

Joan (album)

This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: Joan album – news · newspapers · books · scholar · JSTOR (May 2016) (Learn how and when to remove this message) 1967 studio album by Joan BaezJoanStudio album by Joan BaezReleasedAugust 1967RecordedApril - June 1967StudioVanguard Studios, New York ...

Juara Dunia

Juara DuniaGenre Drama Roman Remaja Olahraga Skenario Serena Luna Daniel Tito Cerita Serena Luna Daniel Tito SutradaraEdy MandalaPemeran Aquene Djorghi Nayla Purnama Rassya Hidayah Aqella Calista Anisa Trihapsari Penggubah lagu temaNoahLagu pembukaJalani Mimpi oleh NoahLagu penutupJalani Mimpi oleh NoahPenata musikLaurensius StevenNegara asalIndonesiaBahasa asliBahasa IndonesiaJmlh. musim1Jmlh. episode14ProduksiProduser eksekutifDavid S. SuwartoProduserAlfian BumuloSinematografiM.H. Su...

 

Aruba Airlines

Aruba Airlines Sea nuestro invitado Airbus A320-200 (P4-AAA) de Aruba Airlines en el Aeropuerto Internacional de Miami (2016) IATAAG OACIARU IndicativoAruba Fundación 2006Inicio 2013Aeropuerto principal Aeropuerto Internacional Reina BeatrixSede central Oranjestad, Aruba ArubaFlota 2Destinos 4 + chárterDirector ejecutivo Hubert Zievinger (Interino)Página web https://www.arubaairlines.com[editar datos en Wikidata] Aruba Airlines (Arubaanse Luchtvaart Maatschappij) N.V., es un...

 

John Roos

American lawyer and diplomat For the South African cricketer, see John Roos (cricketer). For the English baron spelled John Roos or John de Roos, see John de Ros. John RoosUnited States Ambassador to JapanIn officeAugust 20, 2009 – August 12, 2013PresidentBarack ObamaPreceded byTom SchiefferSucceeded byCaroline Kennedy Personal detailsBornJohn Victor Roos (1955-02-14) February 14, 1955 (age 69)San Francisco, California, U.S.Political partyDemocraticAlma materStanford Universit...

Kemp Commission

Tax reform commission This article is part of a series onTaxation in the United States Federal taxation Alternative minimum tax Capital gains tax Corporate tax Estate tax Excise tax Gift tax Generation-skipping transfer tax Income tax Payroll tax Internal Revenue Service (IRS) Internal Revenue Code (IRC) IRS tax forms Revenue by state History Constitutional authority Taxpayer standing Court Protest Evasion Resistance State and local taxation State income tax Property tax Sales tax State and l...

 

Wenzhou rail transit

Rapid transit system serving Wenzhou, China Wenzhou Rail TransitOverviewNative name温州轨道交通LocaleWenzhou, Zhejiang, ChinaTransit typeRapid TransitNumber of lines2Websitewww.wzmtr.comOperationBegan operationJanuary 23, 2019; 5 years ago (2019-01-23)Operator(s)Wenzhou Mass Transit Rail Corporation (WZ-MTR)TechnicalSystem length116.4 km (72.3 mi) System map Wenzhou rail transitSimplified Chinese温州轨道交通Traditional Chinese溫州軌道交�...

 

Irina Bokowa

Irina Bokowa (2009), im Oktober 2009 Irina Georgiewa Bokowa (auch Irina Georgieva Bokova geschrieben, bulgarisch Ирина Георгиева Бокова; * 12. Juli 1952 in Sofia) ist eine bulgarische Politikerin der Bulgarischen Sozialistischen Partei (BSP) und vom 15. November 2009 bis 15. November 2017 Generaldirektorin der UNESCO. Inhaltsverzeichnis 1 Ausbildung und politische Karriere 2 UNESCO 3 Weltkulturerbe im syrischen Krieg 4 Kritik 5 Familie 6 Weblinks 7 Einzelnachweise Ausbildu...

María Alejandra Muñoz

María Alejandra MuñozMuñoz pada tahun 2020 Wakil Presiden Ekuador ke-51PetahanaMulai menjabat 22 Juli 2020PresidenLenín MorenoPendahuluOtto SonnenholznerPenggantiAlfredo Borrero Vega (terpilih) Informasi pribadiLahirc. 1979 (age 40-41)Guayaquil, EkuadorKebangsaanEkuadorianPartai politikConstruye EcuadorAnak4Alma materUniversitas SalamancaUniversidad de Especialidades Espíritu SantoSunting kotak info • L • B María Alejandra Muñoz Seminario (lahir c. 1979) adalah politi...

 

Template talk:Japan-footy-forward-1990s-stub

This template does not require a rating on Wikipedia's content assessment scale.It is of interest to the following WikiProjects:Biography: Sports and Games Biography portalThis template is within the scope of WikiProject Biography, a collaborative effort to create, develop and organize Wikipedia's articles about people. All interested editors are invited to join the project and contribute to the discussion. For instructions on how to use this banner, please refer to the documentation.Biograph...