Cynthia Kenyon graduated valedictorian in chemistry and biochemistry from the University of Georgia in 1976. She received her Ph.D. in 1981 from MIT where, in Graham Walker's laboratory, she looked for genes on the basis of their activity profiles, discovering that DNA-damaging agents activate a battery of DNA repair genes in E. coli. She then did postdoctoral studies with Nobel laureate Sydney Brenner at the MRC Laboratory of Molecular Biology in Cambridge, England, studying the development of C. elegans.
In April 2014, Kenyon was named Vice President of Aging Research at Calico, a new company focused on health, well-being, and longevity. Prior to that, she served as a part-time advisor beginning in November 2013. Kenyon remains affiliated with UCSF as an emeritus professor.
Her early work led to the discovery that Hox genes, which were known to pattern the body segments of the fruit fly (Drosophila) also pattern the body of C. elegans. These findings demonstrated that Hox genes were not simply involved in segmentation, as thought, but instead were part of a much more ancient and fundamental metazoan patterning system.
Michael Klass discovered that lifespan of C. elegans could be altered by mutations, but Klass believed that the effect was due to reduced food consumption (caloric restriction).[2] Thomas Johnson later showed that the 65% life extension effect was due to the mutation itself rather than due to caloric restriction.[3] In 1993, Kenyon's discovery that a single-gene mutation (Daf-2) could double the lifespan of C. elegans and that this could be reversed by a second mutation in daf-16m,[4] sparked an intensive study of the molecular biology of aging, including work by Leonard Guarente and David Sinclair.[1] Kenyon's findings have led to the discovery that an evolutionarily conserved hormone signaling system influences aging in other organisms, perhaps also including mammals.
Kenyon's research prompted her to make personal dietary changes. In 2000, when she discovered that putting sugar on the worms' food shortened their lifespans, she stopped eating high glycemic index carbohydrates and started eating a low-carbohydrate diet.[15][16][17]
She briefly experimented with a calorie restriction diet for two days, but couldn't stand the constant hunger.[16]
^ abDuncan, David Ewing (August 15, 2007). "The Enthusiast". MIT Technology Review.
^Klass MR (1983). "A method for the isolation of longevity mutants in the nematode Caenorhabditis elegans and initial results". Mechanisms of Ageing and Development. 22 (3–4): 279–286. doi:10.1016/0047-6374(83)90082-9. PMID6632998. S2CID6870538.
