Block's first political bid came in the 2015 federal election, when she stood for the Liberal Party in the riding of Saskatoon—University.[3] During the campaign, she spoke to the need for more collaborative relationships between governments at the federal and provincial levels.[4] Block finished third in the race.[5]
After eight years on city council, Block launched a bid for mayor in June 2024.[7] Clark, who served two terms as mayor, announced in January 2024 that he would not be seeking a third term.[8] Block was joined in the race by former city councillor and provincial cabinet minister Gordon Wyant, former four-term mayor Don Atchison, former mayoral challenger Cary Tarasoff, and newcomer Mike Harder.[3] Block campaigned on issues she supported as a councillor, such as increasing density in urban development, including through zoning changes and improved public transit, and revitalizing the downtown core of the city.[2] In addition, she argued for the need for Canadian municipalities to partner together and create more "economies of scale" to combat inflationary pressure, including through working directly with the federal government.[2]
On November 13, Block was elected mayor, receiving approximately 45% of the vote city-wide.[9] The victory made Block the first woman to be elected mayor in Saskatoon's history.[10] Block was inaugurated along with the new city council on November 20, 2024.[11]