Dr. Harry Wolper is an eccentric medical professor teaching at a small Southern California college who is obsessed with making a clone of his wife Lucy who died in childbirth 30 years earlier. Harry hires Boris Lafkin, a struggling pre-med student as his personal assistant to help him with his experiments by obtaining lab equipment and working in his backyard shed in exchange for which Harry gives Boris love life advice in courting an attractive student named Barbara who slowly becomes smitten with Boris. To continue his research into cloning, Harry meets and employs a young woman, named Meli, who practically moves in with him on an agreement to contribute her ovary sample as part of the cloning progress. Meli slowly falls for the much older Harry who begins to question his ethics and vision of true love. Meanwhile, a rival of Harry's, fellow medical professor Dr. Sid Kuhlenbeck, tries to investigate and hinder Harry's cloning plans as part of a ploy to remove Harry from the university to take over Harry's lab for himself. Dr. Kuhlenbeck's plan is to have Harry reassigned to Northfield, an outlying branch of the university where no actual research is conducted, and which apparently serves as little more than a place to send older scientists. Kuhlenbeck's plan backfires after Harry successfully earns a sizable research grant. Because grants are given to individuals, and not institutions, the grant money follows Harry to Northfield, much to Kuhlenbeck's chagrin.
Barbara suffers an aneurysm and is hospitalised by Sid. Her parents welcome Boris into their hearts, but are advised to turn off her life support despite his protestations. Harry gains some time for Boris to talk to Barbara in her coma, and eventually she wakes up. Harry pours his dead wife’s cells into the sea and marries Meli. Everyone chooses to follow him to Northfield.
