Corticotropin-releasing hormone binding protein family

Corticotropin-releasing hormone binding protein (CRH-BP)
Identifiers
SymbolCRH-BP
PfamPF05428
InterProIPR008435
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

Corticotropin-releasing hormone binding protein (CRH-BP) binds corticotropin-releasing hormone (CRH) and several related peptide hormones (urocortin 1, urotensin 1, and sauvagine).[1] It is an ancient, highly conserved protein whose origin predates the divergence of protostomes and deuterostomes.[2]

Corticotropin-releasing hormone (CRH) plays multiple roles in vertebrate species. It is the major hypothalamic releasing factor for pituitary adrenocorticotropin secretion,[2] and is a neurotransmitter or neuromodulator at other sites in the central nervous system. In non-mammalian vertebrates, CRH not only acts as a neurotransmitter and hypophysiotropin, it also acts as a potent thyrotropin-releasing factor,[3] allowing CRH to regulate both the adrenal and thyroid axes, especially in development.

Corticotropin-releasing factor binding protein (CRH-BP) is thought to play an inhibitory role in which it binds CRH and other CRH-like ligands and prevents the activation of CRH receptors 1 and 2. There is however evidence that CRH-BP may also exhibit diverse extra and intracellular roles in a cell specific fashion and at specific times in development.[4]

Human proteins

CRHBP;

References

  1. ^ Ketchesin, Kyle D.; Stinnett, Gwen S.; Seasholtz, Audrey F. (2017-09-03). "Corticotropin-releasing hormone-binding protein and stress: from invertebrates to humans". Stress. 20 (5): 449–464. doi:10.1080/10253890.2017.1322575. ISSN 1025-3890. PMC 7885796. PMID 28436309. S2CID 41347737.
  2. ^ a b Huising, Mark O.; Flik, Gert (May 2005). "The Remarkable Conservation of Corticotropin-Releasing Hormone (CRH)-Binding Protein in the Honeybee ( Apis mellifera ) Dates the CRH System to a Common Ancestor of Insects and Vertebrates". Endocrinology. 146 (5): 2165–2170. doi:10.1210/en.2004-1514. hdl:2066/33202. ISSN 0013-7227. PMID 15718273.
  3. ^ De Groef, Bert; Van der Geyten, Serge; Darras, Veerle M.; Kühn, Eduard R. (March 2006). "Role of corticotropin-releasing hormone as a thyrotropin-releasing factor in non-mammalian vertebrates". General and Comparative Endocrinology. 146 (1): 62–68. doi:10.1016/j.ygcen.2005.10.014. PMID 16337947.
  4. ^ Seasholtz AF, Valverde RA, Denver RJ (2002). "Corticotropin-releasing hormone-binding protein: biochemistry and function from fishes to mammals". J. Endocrinol. 175 (1): 89–97. doi:10.1677/joe.0.1750089. PMID 12379493.
This article incorporates text from the public domain Pfam and InterPro: IPR008435

Read other articles:

List of pilot training institutes in India

Flying schools in India Antonov An-32 transport aircraft of the Indian Air Force In India, civil aviation is regulated by the Directorate General of Civil Aviation (DGCA) which recognizes 35 (as of 2023) Flying Training Organisations (FTO) for flight training and seven (including one in Singapore) Aircraft Type Training Organisations or Approved Training Organisations (ATO) for type rating.[1] In Indian Armed Forces, aircraft are used by the Indian Air Force, the Army Aviation Corps, ...

 

 

BTV (Indonesia)

Untuk kegunaan lain, lihat BTV. Artikel ini bukan mengenai B-Channel atau Biznet Home. BeritaSatu beralih ke halaman ini. Untuk media lain bermerek sama yang segrup, lihat B Universe § Media. BTVNama sebelumnyaQ Channel (1998-2005)QTV (2005-2011)BeritaSatu (2011-2022)JenisJaringan televisiSloganBersatu MenginspirasiNegaraIndonesiaBahasaBahasa IndonesiaPendiriPeter F. GonthaTanggal siaran perdana1 Mei 1998 (siaran percobaan)Tanggal peluncuran29 Mei 1998 (sebagai Q Channel)15 Septem...

 

 

Croix-Rouge sénégalaise

Cet article est une ébauche concernant le Sénégal. Vous pouvez partager vos connaissances en l’améliorant (comment ?) selon les recommandations des projets correspondants. Croix-Rouge sénégalaiseHistoireFondation 1962CadreSigle CRSZone d'activité SénégalType Société nationale du Mouvement international de la Croix-Rouge et du Croissant-RougeSiège DakarPays  SénégalOrganisationSite web www.croix-rouge.snmodifier - modifier le code - modifier Wikidata La Croix-Rouge s...

Archidona

ArchidonaMunicipalityArchidona BenderaLambang kebesaranMunicipal location in the Province of MálagaArchidonaLocation in SpainTampilkan peta Province of MálagaArchidonaArchidona (Andalusia)Tampilkan peta AndalusiaArchidonaArchidona (Spanyol)Tampilkan peta SpanyolKoordinat: 37°06′N 4°23′W / 37.100°N 4.383°W / 37.100; -4.383Koordinat: 37°06′N 4°23′W / 37.100°N 4.383°W / 37.100; -4.383Sovereign state SpainAutonomous community&...

 

 

Serhii Sternenko

Ukrainian activist, lawyer, and YouTuber Serhii SternenkoSternenko in June 2020 in a court in KyivBorn (1995-03-20) 20 March 1995 (age 29)Sadove, Odesa Oblast, UkraineNationalityUkrainianAlma materTaras Shevchenko National University of Kyiv (2022) Odesa University (2019)Occupation(s)Social activist, lawyer, YouTuber Serhii SternenkoYouTube informationChannel @STERNENKO Years active10Subscribers1.78 million (November 2023)[1]Total views739 million (November 2023)&#...

 

 

Daftar Panglima Komando Daerah Militer Jayakarta

Panglima Kodam JayakartaLambang Kodam JayaPetahanaMayjen TNI Mohamad Hasansejak 24 Maret 2023TNI Angkatan DaratKantorMarkas Kodam Jaya, Jakarta Timur, DKI JakartaDibentuk24 Desember 1949Pejabat pertamaLetkol Inf. Daan JahjaSitus webkodamjaya-tniad.mil.id Panglima Komando Daerah Militer Jayakarta atau biasa disingkat Pangdam Jaya/Pangdam Jayakarta adalah jabatan yang diemban oleh seorang perwira tinggi TNI-AD dengan pangkat Mayor Jenderal (Mayjen). Daftar pejabat Berikut adalah nama nama ...

Theodor Schwann

German physiologist (1810–1882) For the American Union Army officer, see Theodore Schwan. Theodor SchwannSchwann in 1857Born(1810-12-07)7 December 1810Neuss, First French EmpireDied11 January 1882(1882-01-11) (aged 71)Cologne, German EmpireEducationHumboldt University of Berlin (1834)University of BonnUniversity of WürzburgKnown forCell theorySchwann cellsPepsinAwardsCopley Medal (1845)Scientific careerFieldsBiology Theodor Schwann (German pronunciation: [ˈteːodoːɐ̯ ˈʃ...

 

 

コルク

この記事は検証可能な参考文献や出典が全く示されていないか、不十分です。出典を追加して記事の信頼性向上にご協力ください。（このテンプレートの使い方）出典検索?: コルク – ニュース · 書籍 · スカラー · CiNii · J-STAGE · NDL · dlib.jp · ジャパンサーチ · TWL（2017年4月） コルクを打ち抜いて作った瓶の栓 コルク（木栓、�...

 

 

Elections in the Sahrawi Arab Democratic Republic

Political elections for public offices in the Sahrawi Arab Democratic Republic Elections in Western Sahara redirects here. For elections in the Moroccan-administered part of Western Sahara, see Elections in Morocco. Politics of the SADR Constitution Nationality law Executive President Brahim Gali Prime Minister Bouchraya Hammoudi Bayoun Legislature Sahrawi National Council President: Hamma Salama Judiciary Constitutional Council Supreme Court Court of Appeal Judicial system Politics Parties: ...

Музей естествознания (Вена)

Музей естественной истории Дата основания 1889 Дата открытия 10 августа 1889 Основатель Франц Иосиф I[1] Местонахождение Вена Адрес Naturhistorisches Museum WienBurgring 7 A-1010 Wien Посетителей в год 564 512 чел. Директор Bernd Lötsch Сайт http://www.nhm-wien.ac.at  Медиафайлы на Викискладе Музей естестве...

 

 

Бисексуальность

Флаг гордости бисексуалов Бисексуальность      Сексуальные ориентации Бисексуальность Пансексуальность Полисексуальность Моносексуальность Сексуальные идентичности Би-любопытство Гетерогибкость и гомогибкость Сексуальная текучесть Исследования Шк...

 

 

Waterloo, London

Human settlement in EnglandWaterlooWaterlooLocation within Greater LondonOS grid referenceTQ311797• Charing Cross1 mi (1.6 km) WLondon boroughLambethCeremonial countyGreater LondonRegionLondonCountryEnglandSovereign stateUnited KingdomPost townLONDONPostcode districtSE1Dialling code020PoliceMetropolitanFireLondonAmbulanceLondon UK ParliamentVauxhallLondon AssemblyLambeth and Southwark List of places UK England London 51°30�...

詹姆斯·卡拉漢

此條目可参照英語維基百科相應條目来扩充。 (2023年12月1日)若您熟悉来源语言和主题，请协助参考外语维基百科扩充条目。请勿直接提交机械翻译，也不要翻译不可靠、低品质内容。依版权协议，译文需在编辑摘要注明来源，或于讨论页顶部标记{{Translated page}}标签。 此條目需要补充更多来源。 (2021年4月4日)请协助補充多方面可靠来源以改善这篇条目，无法查证的内容可能�...

 

 

Bernardo di Vienne

San Bernardo di Vienne (o di Romans)Statua di San Bernardo nella chiesa di Notre-Dame di Ambronay Arcivescovo  NascitaIzernore, 778 MorteRomans-sur-Isère, 22 gennaio 841 Venerato daChiesa cattolica Canonizzazione944 Ricorrenza22 gennaio Manuale Bernardo di Viennevescovo della Chiesa cattolicaIncarichi ricopertiArcivescovo di Vienne  Nato778 ad Izernore Consacrato vescovo810 Deceduto22 gennaio 841 a Romans-sur-Isère   Manuale Bernardo di Vienne, o Bernardo di Romans, in f...

 

 

Vitesse à la bouche

La vitesse initiale est la vitesse à laquelle un projectile sort d'une arme. La vitesse à la bouche est celle à laquelle il sort de la « bouche » du canon d'une arme, qui est son extrémité la plus proche de la cible. Elles sont souvent notées « V0 ». Terminologie Vitesse initiale et vitesse à la bouche sont deux concepts qui caractérisent un projectile non autopropulsé, par exemple une balle ou un obus tirés grâce à une charge propulsive telle que la poudre...

دوري السوبر الألباني 1995–96

دوري السوبر الألباني 1995–96 تفاصيل الموسم دوري السوبر الألباني  النسخة 57  البلد ألبانيا  التاريخ بداية:2 سبتمبر 1995  نهاية:8 مايو 1996  المنظم اتحاد ألبانيا لكرة القدم  البطل نادي تيرانا  مباريات ملعوبة 306   عدد المشاركين 18   دوري السوبر الألباني 1994–95  د�...

 

 

Hof van Twente

This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: Hof van Twente – news · newspapers · books · scholar · JSTOR (August 2022) (Learn how and when to remove this message) Municipality in Overijssel, NetherlandsHof van TwenteMunicipalityFarmhouse in Deldeneresch FlagCoat of armsLocation in OverijsselCoordinates: ...

 

 

سورة يوسف

سورة يوسف سورة يوسف الترتيب في المصحف 12 إحصائيات السُّورة عدد الآيات 111 عدد الكلمات 1776 عدد الحروف 7166[1] الجزء 12-13 تَرتيب السُّورة في المُصحَف سورة هود سورة الرعد نُزول السُّورة النزول مكية ترتيب نزولها 52 سورة هود سورة الحجر نص السورة برواية حفص لقراءة عاصم برواية ورش لق�...

سباق جائزة لا مارسيليس الكبرى 2012

يفتقر محتوى هذه المقالة إلى الاستشهاد بمصادر. فضلاً، ساهم في تطوير هذه المقالة من خلال إضافة مصادر موثوق بها. أي معلومات غير موثقة يمكن التشكيك بها وإزالتها. (ديسمبر 2018) سباق جائزة لا مارسيليس الكبرى 2012 تفاصيل السباقسلسلة33. سباق جائزة لامارسييز الكبرىمسابقاتطواف أوروبا لل�...

 

 

Alexey Veller

Russian politician In this name that follows Eastern Slavic naming customs, the patronymic is Borisovich and the family name is Veller. Alexey VellerАлексей ВеллерMember of the State Duma for Krasnoyarsk KraiIncumbentAssumed office 12 October 2021Preceded byRaisa KarmazinaConstituencyYeniseysk (No. 56)Member of the State Duma for Murmansk OblastIn office5 October 2016 – 12 October 2021Preceded byconstituency re-establishedSucceeded byTatiana KusaykoConstituency...