The club's name was chosen as a tribute to lawyer and journalist Mariano Moreno, who played a decisive role in the Primera Junta, the first Government of Argentina.
Mariano Moreno has a strong rivalry with Los Matreros, the other team from the Zona Oeste of the Greater Buenos Aires. The club's best campaign was in 2010 when Mariano Moreno promoted to the Grupo I (the first division of the Torneo de la URBA), after defeating Club San Andrés de Benavídez. T
The team lasted there only one season so in 2011 Mariano Moreno was relegated to second division after finishing 15 in Zona Reubicación. In 2012 the club won the Grupo II championship.[2]