Smith made his AFL debut on 1 April 2012 in the opening round of the 2012 AFL season against the West Coast Eagles. Smith was one of the Bulldogs' best players, gathering 13 possessions and kicking 4 goals, before being substituted off the field just before 3 quarter time due to severe cramping.[2]
Clay Smith announced his retirement from AFL football on 9 July 2018 due to persistent injuries.