In 1993, she formed her first group, Helen, with Barry Mirochnick, Paul James, and Chang. Helen broke up in 1995, and in 1996 Fellows teamed up with singer-songwriter Keri McTighe, Barry Mirochnick, Keith McLeod and Peggy Messing, to form Special Fancy. The group released one album, King Me.
In 2000 Fellows released her debut solo album, 2 Little Birds. This was followed by The Last One Standing in 2002, Paper Anniversary in 2005, and Nevertheless in 2007. These albums feature Leanne Zacharias (cello), Jason Tait (drums, vibraphone), Barry Mirochnick (drums, vocals), John K. Samson (vocals, guitar), Keith McLeod (mandolin), Monica Guenter (viola), Greg Smith (bass), Ed Reifel (percussion), and Cristina Zacharias (violin).
In 2006, Fellows and Samson recorded The Old House, an album intended only as a Christmas gift for friends and family, although they released two songs, "Taps Reversed" and "Good Salvage", for airplay on CBC Radio 3 in early 2007. Fellows and Samson also performed live on the network on 17 March 2007, to mark the final night of the network's terrestrial simulcast on CBC Radio 2.
Fellows also composes music for dance, film, and television. She scored part of Clive Holden's Trains of Winnipeg film series, as well as collaborating with Tait and Samson on the associated album. In 2007, she wrote several songs for a dance piece by choreographer Susie Burpee; they were later included on her fourth solo album, Nevertheless, which was released on 6 November 2007.
Fellows has also toured as a member of The Pan-Canadian New Folk Ensemble with Kim Barlow and Old Man Luedecke,[3] and often collaborates with visual artist Shary Boyle.
She was artist-in-residence at Le Musée de Saint-Boniface Museum in Winnipeg for 2009. Her fifth studio album, Femmes de chez nous includes a live performance film/DVD of the September 2009 premiere of Reliquary/Reliquaire, the commissioned performance work she created for the museum.[4]
In 2018, Fellows launched her own online store, Vivat Virtute, to sell her music and other craft and art projects.[10] Her first release through Vivat Virtute was the album Roses on the Vine,[10] and she followed up in 2022 with Stuff We All Get.[11] In February 2023, Fellows and Samson released Hold Music, an album of almost entirely instrumental music except one song with vocals by Samson, with Vivat Virtute credited as the band name.