Projected to go undrafted by Sports Illustrated, who criticized his lack of "balance, body control and ability in space,"[3] Kuper was ranked as the No. 28 offensive guard available in the 2006 NFL draft.[4] Kuper was eventually selected in the fifth round, 161st overall, by the Denver Broncos.[5] He was the highest selected North Dakota lineman since Todd Thomas in 1981.
Kuper started 79-of-90 games played (68 at right guard) while playing his entire eight-year NFL career with the Broncos.
On June 4, 2010, the Broncos announced that they had signed Kuper to a five-year deal worth $25.5 million.[6] The new contract made him the second-highest-paid offensive lineman in Broncos' history, second only to former left tackle Matt Lepsis.
In 2010, the Denver Broncos announced that Kuper had been selected as co-captain of the Broncos offense, along with Kyle Orton and Daniel Graham.[7]
During the regular season finale in 2011 against the Kansas City Chiefs, Kuper suffered a gruesome broken ankle that ended his season. That season Chris Kuper made the Pro Bowl but withdrew due to the injury and needed surgery.[8]
A three-time captain, Kuper was recipient of the Ed Block Courage Award in 2012 as voted on by his teammates.[9]
During the 2015 high school football season, Kuper was an offensive line coach at Columbine High School in Littleton, Colorado.
On January 23, 2016, Kuper was hired by Miami Dolphins as offensive quality control coach.[11] He then spent two seasons (2017–18) as the assistant offensive line coach for Miami.
On January 22, 2019, the Denver Broncos hired Kuper as their assistant offensive line coach.[12]