Chenghua Gu
Professor of Neurobiology
Chenghua Gu is a Professor of Neurobiology at the Harvard Medical School where her research focuses on the Blood–brain barrier .[ 1] She is also part of the Harvard Brain Science Initiative and has won numerous awards for her groundbreaking research on the brain's vascular component.
Education
Gu earned her Ph.D . at Cornell Medical School . She then joined the lab of David Ginty at the Johns Hopkins University School of Medicine where she studied the role of semaphorin signaling in vascular development.[ 2] [ 3]
Research
Gu's research focuses on the development of the blood-brain barrier and its interaction with neuronal networks.[ 4] [ 5] She uses experimental techniques such as Two-photon excitation microscopy , mouse genetics and computational models to study neurovascular coupling, the regulation of blood flow by changes in neuronal activity, and vascular patterning.[ 6] Her laboratory has recently published on the importance of the inhibition of transcytosis for maintaining blood-brain barrier integrity and how the mechanisms regulating transcytosis levels could be manipulated to aid the entry of therapeutics into the central nervous system.[ 7] [ 8]
Award and honors
Allen Distinguished Investigator Award, 2018[ 9]
Howard Hughes Medical Institute Faculty Scholar, 2016[ 10]
National Institutes of Health Director's Pioneer Award, 2014[ 11]
Alfred P. Sloan Research Fellowship, 2008[ 12]
Whitehall Foundation Award, 2007[ 12]
Klingenstein Fellowship Award, 2007[ 13]
March of Dimes Foundation Award, 2007[ 12]
References
^ "Chenghua Gu | Department of Neurobiology" . neuro.hms.harvard.edu . Retrieved 2019-12-07 .
^ Gu, Chenghua; Yoshida, Yutaka; Livet, Jean; Reimert, Dorothy V.; Mann, Fanny; Merte, Janna; Henderson, Christopher E.; Jessell, Thomas M.; Kolodkin, Alex L.; Ginty, David D. (2005-01-14). "Semaphorin 3E and Plexin-D1 Control Vascular Pattern Independently of Neuropilins" . Science . 307 (5707): 265– 268. Bibcode :2005Sci...307..265G . doi :10.1126/science.1105416 . ISSN 0036-8075 . PMID 15550623 . S2CID 36470855 .
^ Gu, Chenghua; Rodriguez, E. Rene; Reimert, Dorothy V.; Shu, Tianzhi; Fritzsch, Bernd; Richards, Linda J.; Kolodkin, Alex L.; Ginty, David D. (July 2003). "Neuropilin-1 Conveys Semaphorin and VEGF Signaling during Neural and Cardiovascular Development" . Developmental Cell . 5 (1): 45– 57. doi :10.1016/s1534-5807(03)00169-2 . ISSN 1534-5807 . PMC 3918747 . PMID 12852851 .
^ Ben-Zvi, Ayal; Lacoste, Baptiste; Kur, Esther; Andreone, Benjamin J.; Mayshar, Yoav; Yan, Han; Gu, Chenghua (2014-05-22). "MSFD2A is critical for the formation and function of the blood brain barrier" . Nature . 509 (7501): 507– 511. Bibcode :2014Natur.509..507B . doi :10.1038/nature13324 . ISSN 0028-0836 . PMC 4134871 . PMID 24828040 .
^ Lacoste, Baptiste; Comin, Cesar H.; Ben-Zvi, Ayal; Kaeser, Pascal S.; Xu, Xiaoyin; Costa, Luciano da F.; Gu, Chenghua (2014-09-03). "Sensory-related neural activity regulates the structure of vascular networks in the cerebral cortex" . Neuron . 83 (5): 1117– 1130. doi :10.1016/j.neuron.2014.07.034 . ISSN 0896-6273 . PMC 4166422 . PMID 25155955 .
^ Lacoste, Baptiste; Gu, Chenghua (November 2015). "Control of cerebrovascular patterning by neural activity during postnatal development" . Mechanisms of Development . 138 Pt 1: 43– 49. doi :10.1016/j.mod.2015.06.003 . ISSN 0925-4773 . PMC 4663105 . PMID 26116138 .
^ Andreone, Benjamin J.; Chow, Brian Wai; Tata, Aleksandra; Lacoste, Baptiste; Ben-Zvi, Ayal; Bullock, Kevin; Deik, Amy A.; Ginty, David D.; Clish, Clary B.; Gu, Chenghua (2017-05-03). "Blood-brain barrier permeability is regulated by lipid transport-dependent suppression of caveolae-mediated transcytosis" . Neuron . 94 (3): 581–594.e5. doi :10.1016/j.neuron.2017.03.043 . ISSN 0896-6273 . PMC 5474951 . PMID 28416077 .
^ Chow, Brian Wai; Gu, Chenghua (2017-03-22). "Gradual suppression of transcytosis governs functional blood-retinal barrier formation" . Neuron . 93 (6): 1325–1333.e3. doi :10.1016/j.neuron.2017.02.043 . ISSN 0896-6273 . PMC 5480403 . PMID 28334606 .
^ "Three Harvard Medical School scientists receive prestigious Allen awards" . EurekAlert! . Retrieved 2019-12-07 .
^ "Faculty Scholars Program" . HHMI.org . Retrieved 2019-12-07 .
^ "NIH Director's Pioneer Award Program - 2014 Award Recipients | NIH Common Fund" . commonfund.nih.gov . Retrieved 2019-12-07 .
^ a b c "Brain vasculature at the neuro-immune interface" . alleninstitute.org . Retrieved 2019-12-07 .
^ "The Esther A. & and Joseph Klingenstein Fund, Inc" . www.klingfund.org . Retrieved 2019-12-07 .
External links