Little was elected as a Democrat to the Sixty-ninth Congress (March 4, 1925 – March 3, 1927). He was an unsuccessful candidate for re-election in 1926 to the Seventieth Congress. He resumed the practice of law. He was an unsuccessful candidate for Governor of Kansas in 1928. He died in Olathe, Kansas on September 29, 1952, and was interred in Olathe Cemetery.