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The Charlotte District is a line operated by Norfolk Southern Railway. The line is part of the Norfolk Southern Coastal Division; the district runs between Greenville, South Carolina, and Linwood, North Carolina.

Intermodal, manifest, coal trains, and Amtrak run on the Charlotte District. 20-30 trains a day run through Charlotte, North Carolina, while between C.P. Charlotte Junction (a connector to the R-Line) and Gaffney, South Carolina, it is usually 10-18 trains a day. Most regional trains do not need track authorities from the Charlotte dispatcher; however, they are given to track supervisors, signal maintainers, locals, or trains that need to do the switching.

• List of Norfolk Southern Railway lines