After pitching in the low minor leagues from 1967 to 1969 with the Ogden Dodgers, Santa Barbara Dodgers and Albuquerque Dodgers with limited success, Hough's career and fortunes changed dramatically when he learned how to throw a knuckleball in spring training in 1970, leading to a successful season with the Spokane Indians in AAA, where he led the Pacific Coast League in saves and posted a 1.95 ERA.
Los Angeles Dodgers
He made his major league debut against the Pittsburgh Pirates in 1970 but did not join the Dodgers bullpen full-time until the 1973 season. He became a top reliever for the Dodgers from 1973 until he was sold to the Texas Rangers in 1980. With the Dodgers, he was one of the pitchers who served up one of the three home runs that New York Yankees slugger Reggie Jackson hit on three straight pitches in Game 6 of the 1977 World Series.
Texas Rangers
He was converted into a starting pitcher in Texas, where he pitched from 1980 to 1990, making his only All-Star team in 1986. He left Texas as the franchise leader in wins (139), strikeouts (1,452), innings pitched (2,308), complete games (98), and losses (123), which all still stand as club records as of 2024. He was famous for his "dancing knuckleball" pitch that he threw around 80% of the time. Hough complemented his knuckleball with a fastball and slider. Hough was well known for throwing a large number of complete games each season and led the league in 1984 with 17. In his last complete game of the season, the opposing pitcher, Mike Witt of the California Angels, hurled a perfect game.
He pitched for the Chicago White Sox from 1991 to 1992, where, at 43 years old, he was a teammate of 43-year-old Carlton Fisk.
Florida Marlins
He joined the expansion Florida Marlins for the 1993 season and started the first regular season game in team history, on April 5, pitching six innings for the win as the Marlins defeated the Dodgers 6–3. He retired at age 46 after the 1994 season. He was the last active player who was born in the 1940s.
Career totals
During a 25-season career, Hough compiled 216 wins, 216 losses, 2,362 strikeouts and a 3.75 earned run average. His 216 wins rank 86th all-time on the all-time win list, tied with Wilbur Cooper and Curt Schilling. However, Hough also recorded 216 losses, making him the winningest pitcher in history to have lost as many games as he won.