Centpropazine

Centpropazine
Clinical data
Other namesCPZ; CTZ
Routes of
administration		Oral[1]
Identifiers
  • 1-[4-[2-hydroxy-3-(4-phenylpiperazin-1-yl)propoxy]phenyl]propan-1-one
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC22H28N2O3
Molar mass368.477 g·mol−1
3D model (JSmol)
  • CCC(=O)C1=CC=C(C=C1)OCC(CN2CCN(CC2)C3=CC=CC=C3)O
  • InChI=1S/C22H28N2O3/c1-2-22(26)18-8-10-21(11-9-18)27-17-20(25)16-23-12-14-24(15-13-23)19-6-4-3-5-7-19/h3-11,20,25H,2,12-17H2,1H3
  • Key:ZQPXSRTZFYHSFB-UHFFFAOYSA-N

Centpropazine (CPZ, CTZ) is an experimental antidepressant which was under development for the treatment major depressive disorder in India but was never marketed.[1][2][3] It is described as having imipramine-like clinical effects, reversing reserpine-induced effects in animals, and potentiating amphetamine-induced effects in animals.[3] The mechanism of action of centpropazine is unknown.[4] The drug reached phase 3 clinical trials prior to the discontinuation of its development.[1] It was first described in the scientific literature by 1980.[3][5]

References

  1. ^ a b c "Centpropazine". AdisInsight. Springer Nature Switzerland AG. 10 December 2013. Retrieved 27 September 2024.
  2. ^ Avasthi A, Grover S, Aggarwal M (January 2010). "Research on antidepressants in India". Indian Journal of Psychiatry. 52 (Suppl 1): S341–S354. doi:10.4103/0019-5545.69263. PMC 3146188. PMID 21836704.
  3. ^ a b c Kaiser C, Bondinell WE (1981). "Chapter 1. Antidepressants". Annual Reports in Medicinal Chemistry. Vol. 16. Elsevier. p. 1–10. doi:10.1016/s0065-7743(08)61268-3. ISBN 978-0-12-040516-9. ISSN 0065-7743.
  4. ^ shrafuzzaman M, Ji SH, Ahn H, Chung HW, Choi D, Park JJ, Go M, Pyo JI, Shafioul AS, Lee DH, Chi SG (29 March 2023). "Identification of 1-phenoxy-3-(piperazin-1-yl)propan-2-ol derivatives as novel triple reuptake inhibitors". Bulletin of the Korean Chemical Society. 44 (7). Wiley: 596–599. doi:10.1002/bkcs.12693. ISSN 1229-5949.
  5. ^ Singh H, Chawla AS, Kapoor VK (1985). "Medicinal chemistry research in India". Progress in Medicinal Chemistry. 22: 243–266. doi:10.1016/s0079-6468(08)70232-7. ISBN 978-0-444-80668-0. PMID 2873624.