The neighborhood's northern border is Post Street, the eastern border is Van Ness Avenue, the southern border is Eddy Street and the western border is Laguna Street.[4]
It is home to large condominium and apartment towers, plus numerous churches built atop the hill, including St. Mary's Cathedral, St. Mark's Lutheran Church, The First Unitarian Church of San Francisco, and the Hamilton Baptist Church.
The neighborhood's former Cathedral Hill Hotel at Van Ness and Geary Streets was torn down and replaced by a new earthquake-proof California Pacific Medical Center hospital between 2013 and 2021.[5]