CHST7

CHST7
Identifiers
AliasesCHST7, C6ST-2, GST-5, carbohydrate sulfotransferase 7
External IDsOMIM: 300375; MGI: 1891767; HomoloGene: 10531; GeneCards: CHST7; OMA:CHST7 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

56548

60322

Ensembl

ENSG00000147119

ENSMUSG00000037347

UniProt

Q9NS84

Q9EP78

RefSeq (mRNA)

NM_019886

NM_021715

RefSeq (protein)

NP_063939

NP_068361

Location (UCSC)Chr X: 46.57 – 46.6 MbChr X: 19.93 – 19.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Carbohydrate sulfotransferase 7 is an enzyme that in humans is encoded by the CHST7 gene.[5][6]

Function

This gene belongs to the sulfotransferase gene family. Sulfotransferases generate sulfated glycosaminoglycan (GAG) moieties during chondroitin sulfate biosynthesis. They create considerable structural diversity among chondroitin sulfates by transferring sulfate with remarkable specificity for the underlying oligosaccharide substrate. This gene product mainly transfers sulfate to N-acetylgalactosamine. The regulated expression of each member of this gene family may be an important determinant of sulfated GAGs expression and the associated function of chondroitin sulfates as regulators of many biologic processes. This gene is part of a gene cluster on chromosome Xp11.23.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000147119 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037347 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kitagawa H, Fujita M, Ito N, Sugahara K (Aug 2000). "Molecular cloning and expression of a novel chondroitin 6-O-sulfotransferase". J Biol Chem. 275 (28): 21075–80. doi:10.1074/jbc.M002101200. PMID 10781596.
  6. ^ a b "Entrez Gene: CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7".

Further reading


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