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CENPI
Identifiers
Aliases	CENPI, CENP-I, FSHPRH1, LRPR1, Mis6, centromere protein I
External IDs	OMIM: 300065; MGI: 2147897; HomoloGene: 4899; GeneCards: CENPI; OMA:CENPI - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	101,166,126 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	133,263,388 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; ventricular zone; ; gonad; ; ganglionic eminence; ; testicle; ; stromal cell of endometrium; ; smooth muscle tissue; ; bone marrow; ; rectum; ; trabecular bone;
	Top expressed in
	hand; ; tail of embryo; ; dermis; ; genital tubercle; ; otic vesicle; ; abdominal wall; ; endothelial cell of lymphatic vessel; ; ventricular zone; ; renal corpuscle; ; spermatid;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	chromosome; chromosome, centromeric region; nucleoplasm; kinetochore; nucleus; cytosol; nuclear body;
Biological process	sex differentiation; centromere complex assembly; CENP-A containing chromatin assembly;
	Sources:Amigo / QuickGO
Orthologs
	2491
	102920
	ENSG00000102384
	ENSMUSG00000031262
	Q92674
	Q8K1K4
	NM_006733; NM_001318521; NM_001318523; NM_001386188
	NM_145924; NM_001305631
	NP_001305450; NP_001305452; NP_006724
	NP_001292560; NP_666036
	Wikidata
View/Edit Human	View/Edit Mouse

Centromere protein I is a protein that in humans is encoded by the CENPI gene.^[5]^[6]

Function

The product of this gene is involved in the response of gonadal tissues to follicle-stimulating hormone. This gene is also a potential candidate for human X-linked disorders of gonadal development and gametogenesis.^[6] CENPI is a target gene of the transcription factor E2F.^[7] Additionally, CENPI expression is increased in breast cancer and this has been shown to cause chromosome instability in breast cancer cells.^[7]