After meeting actor/director Michael Landon, Thames was cast in the NBC television network dramatic television series Father Murphy in 1981 at the age of eleven opposite actor and former NFL athlete Merlin Olsen. The series ran for two seasons and ended in 1983. The following year, he was cast in Johnny Dangerously, playing the part of actor Michael Keaton's character as a child,[1] and appeared in a starring role in the Mick Jagger-penned dramatic film Blame It on the Night.[2]
In 2001, he appeared in Don's Plum as the title character, "Don Plum". In 2004, he co-starred with James Vallo in the independent sci-fi comedy Space Daze which was distributed by Troma Entertainment in 2005 and then reprised his role in the 2009 sequel Spaced Out. In 2007, he teamed up again with Vallo and Space Daze writer/director John Wesley Norton playing the lead role in the then titled Working Title which was later released as Not Another B Movie in 2011 (also distributed by Troma).[citation needed]
Byron Thames married actress Lisa Alpert in 1993. They had one son together, singer and actor Hudson Thames. They divorced in 1995 and he married actress Tricia Leigh Fisher in August 2007. The couple resides in Hollywood, California, with their child, as well as their children from his prior marriage and her previous relationship.[3]