A native of Paris,[3] Le Friant began DJing in the 1980s under the name Chris the French Kiss. During this time he was more influenced by hip hop and jazz music and created music projects such as The Mighty Bop and Reminiscence Quartet, the latter with an ensemble of musicians and where Le Friant used the alias Desmond K.
In 1998 Le Friant adopted name of Bob Sinclar after the titular character from the 1973 film Le Magnifique. He became known for popularising the "French touch" of house music with heavy use of sampled and filtered disco strings. He describes his musical style as inspired by "peace, love, and house music".[4]
In the 2010s, Sinclar became a very prolific music producer. In 2011, he released a song with Italian showgirl Raffaella Carrà called "Far l'amore", a remixed version of Carrà's 1976 song "A far l'amore comincia tu". In 2013, Sinclar released a single called "Summer Moonlight", while in 2015 he collaborated with Dawn Tallman for a track titled "Feel the Vibe". In 2016, he released the track "Someone Who Needs Me", under the label Spinnin' Records, with whom he also released a collaboration with Akon, titled "'Til the Sun Rise Up". In June 2018, he released a single called "I Believe", that was very popular, particularly in Italy and other parts of Europe. In May 2021, he collaborated with the vocalist Molly Hammar to produce the song "We Could Be Dancing".