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Big Jeff Pfeffer
Big Jeff Pfeffer
	Pitcher
	Born: March 31, 1882; Champaign, Illinois, U.S.
	Died: December 19, 1954 (aged 72); Kankakee, Illinois, U.S.
	Batted: Right Threw: Right
MLB debut
	April 15, 1905, for the Chicago Cubs
Last MLB appearance
	October 9, 1911, for the Boston Rustlers
MLB statistics
Win–loss record	31–39
Earned run average	3.30
Strikeouts	317
	Stats at Baseball Reference
Teams
	Chicago Cubs (1905); Boston Beaneaters/Doves (1906–1908); Chicago Cubs (1910); Boston Rustlers (1911);
Career highlights and awards
	Pitched a no-hitter on May 8, 1907;

Francis Xavier "Big Jeff" Pfeffer (March 31, 1882 – December 19, 1954) was an American Major League pitcher from 1905 to 1911. He threw a no-hitter in 1907. He was the older brother of Jeff Pfeffer.

Pfeffer attended the University of Illinois. He made his MLB debut on April 15, 1905 for the Chicago Cubs and had a 4-4 record for them that season. He missed out on the 1906 World Series, going to Boston, where he had his most active season with a record of 13-22 for the 1906 season. He finished second in the National League that season in complete games and strikeouts.

Early the following season, Pfeffer pitched a no-hitter on May 8, 1907, with the Boston Doves defeating Cincinnati 6-0.