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BNIPL
Identifiers
Aliases	BNIPL, BNIP-S, BNIPL-1, BNIPL-2, BNIPL1, BNIPL2, BNIPS, PP753, BCL2/adenovirus E1B 19kD interacting protein like, BNIP-Salpha, BNIP-Sbeta, BCL2 interacting protein like
External IDs	OMIM: 611275; MGI: 2384749; HomoloGene: 15900; GeneCards: BNIPL; OMA:BNIPL - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	151,047,720 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	95,158,504 bp
RNA expression pattern
	Top expressed in
	skin of arm; ; skin of abdomen; ; amniotic fluid; ; skin of leg; ; skin of thigh; ; skin of hip; ; gingival epithelium; ; oral cavity; ; mucosa of pharynx; ; buccal mucosa cell;
	Top expressed in
	lip; ; esophagus; ; zone of skin; ; urinary bladder; ; urethra; ; female urethra; ; morula; ; male urethra; ; epithelium of urethra; ; epithelium of male urethra;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; identical protein binding; exopolyphosphatase activity;
Cellular component	cytosol; nucleus; cytoplasm;
Biological process	regulation of growth rate; negative regulation of cell population proliferation; apoptotic process; polyphosphate catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	149428
	171388
	ENSG00000163141
	ENSMUSG00000028115
	Q7Z465
	Q99JU7
	NM_001159642; NM_138278; NM_138279
	NM_001168356; NM_134253
	NP_001153114; NP_612122
	NP_001161828; NP_599014
	Wikidata
View/Edit Human	View/Edit Mouse

Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein is a protein that in humans is encoded by the BNIPL gene.^[5]^[6]^[7]

Interactions

BNIPL has been shown to interact with:

BCL2-like 1,^[8]^[9]
Bcl-2,^[8]^[9]
CDC42,^[8]
GFER,^[5] and
Macrophage migration inhibitory factor.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163141 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028115 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b ^c Shen L, Hu J, Lu H, Wu M, Qin W, Wan D, Li YY, Gu J (Apr 2003). "The apoptosis-associated protein BNIPL interacts with two cell proliferation-related proteins, MIF and GFER". FEBS Letters. 540 (1–3): 86–90. doi:10.1016/S0014-5793(03)00229-1. PMID 12681488.
^ Zhou YT, Soh UJ, Shang X, Guy GR, Low BC (Mar 2002). "The BNIP-2 and Cdc42GAP homology/Sec14p-like domain of BNIP-Salpha is a novel apoptosis-inducing sequence". The Journal of Biological Chemistry. 277 (9): 7483–92. doi:10.1074/jbc.M109459200. PMID 11741952.
^ "Entrez Gene: BNIPL BCL2/adenovirus E1B 19kD interacting protein like".
^ ^a ^b ^c Qin W, Hu J, Guo M, Xu J, Li J, Yao G, Zhou X, Jiang H, Zhang P, Shen L, Wan D, Gu J (Aug 2003). "BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis". Biochemical and Biophysical Research Communications. 308 (2): 379–85. doi:10.1016/s0006-291x(03)01387-1. PMID 12901880.
^ ^a ^b Yasuda M, Han JW, Dionne CA, Boyd JM, Chinnadurai G (Feb 1999). "BNIP3alpha: a human homolog of mitochondrial proapoptotic protein BNIP3". Cancer Research. 59 (3): 533–7. PMID 9973195.

External links

Human BNIPL genome location and BNIPL gene details page in the UCSC Genome Browser.

Qin W, Hu J, Guo M, Xu J, Li J, Yao G, Zhou X, Jiang H, Zhang P, Shen L, Wan D, Gu J (Aug 2003). "BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis". Biochemical and Biophysical Research Communications. 308 (2): 379–85. doi:10.1016/S0006-291X(03)01387-1. PMID 12901880.
Xie L, Qin WX, He XH, Shu HQ, Yao GF, Wan DF, Gu JR (May 2004). "Differential gene expression in human hepatocellular carcinoma Hep3B cells induced by apoptosis-related gene BNIPL-2". World Journal of Gastroenterology. 10 (9): 1286–91. doi:10.3748/wjg.v10.i9.1286. PMC 4622767. PMID 15112343.
Xie L, Qin WX, Li JJ, He XH, Shu HQ, Yao GF, Wan DF, Gu JR (Sep 2005). "cDNA expression array analysis of gene expression in human hepatocarcinoma Hep3B cells induced by BNIPL-1". Acta Biochimica et Biophysica Sinica. 37 (9): 618–24. doi:10.1111/j.1745-7270.2005.00086.x. PMID 16143817.
Valencia CA, Cotten SW, Liu R (Dec 2007). "Cleavage of BNIP-2 and BNIP-XL by caspases". Biochemical and Biophysical Research Communications. 364 (3): 495–501. doi:10.1016/j.bbrc.2007.10.018. PMID 17961507.