Lopez-Liguori was born and raised in Aix-en-Provence. His parents are both pieds-noirs who were born in French Algeria of Spanish and Italian origin. He was a semi-professional rugby player until suffering an injury in 2012.[1]
He has claimed he was interested in politics at school but stated the Charlie Hebdo shooting influenced his decision to become politically active. He campaigned for Nicolas Dupont-Aignan during the 2017 French presidential election before joining the National Rally in 2019. He was employed as a researcher on European international affairs in the European Parliament and worked as an assistant to National Rally MEP Jean-Lin Lacapelle. He was elected as a municipal councilor of Sète in 2020 for the FN.[2] He contested the seat of Hérault's 7th constituency during the 2022 French legislative election. During the election, incumbent deputy Christophe Euzet failed to make the second round leaving Lopez-Liguori and French Communist Party candidate (running affiliated to NUPES) Garbiel Blasco. During the second round he defeated Blasco and was elected to represent the constituency.[3][4]