On 20 September 1378 the cardinals elected Antipope Clement VIIpope in opposition to Pope Urban VI, whom they had come to distrust. The existence of two popes in opposition to one another, called the Western Schism, led to escalating international crises as the kings of Europe were forced to choose sides. On 29 November Wenceslaus's father Charles IV, Holy Roman Emperor died, and Wenceslaus acceded to the throne. Civil unrest in Bohemia prevented Wenceslaus from effectively administering the empire; he declined even to have a coronation ceremony as Holy Roman Emperor.
Because of Wenceslaus's weak rule and his failure to stamp out civil unrest or resolve the Western Schism, three of the prince-electors of the empire convened to remove him at the Imperial election of 22 May 1400. However, the remaining electors, including Wenceslaus himself, did not accept the results of the election, and their candidate, Frederick I, Duke of Brunswick-Lüneburg, was murdered on 5 June.
Now four electors convened to depose Wenceslaus. They were:
As Wenceslaus and the electors of Saxony and Brandenburg were absent, Wenceslaus did not recognize the validity of his deposition or Rupert's election. Neither did the Free Imperial City of Aachen allow him entrance. He was therefore crowned Holy Roman Emperor at Cologne on January 6, 1401 by Frederick III. Wenceslaus was arrested in March 1402 by his brother Sigismund, who would later become Holy Roman Emperor himself, ending the resistance of his partisans.