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Joint Pain
Joint Pain
Specialty	Rheumatology

Arthralgia (from Greek arthro- 'joint' and -algos 'pain') literally means 'joint pain'.^[1]^[2] Specifically, arthralgia is a symptom of injury, infection, illness (in particular arthritis), or an allergic reaction to medication.^[3]

According to MeSH, the term arthralgia should only be used when the condition is non-inflammatory, and the term arthritis should be used when the condition is inflammatory.^[4]

Causes

The causes of arthralgia are varied and range, from a joints perspective, from degenerative and destructive processes such as osteoarthritis and sports injuries to inflammation of tissues surrounding the joints, such as bursitis.^[5] These might be triggered by other things, such as infections or vaccinations.^[6]

Cause	Mono- or polyarticular	Speed of onset
Rheumatoid arthritis	Polyarticular ^[7]	Weeks–months^[8]
Systemic lupus erythematosus	Polyarticular^[7]	Months^[9]
Viral arthritis	Polyarticular^[7]
Ehlers-Danlos Syndrome	^[10]
Reactive arthritis	Polyarticular^[7]
Rheumatic fever	Polyarticular^[7]
Lyme disease	Polyarticular^[7]
Gonococcal arthritis	Polyarticular^[7]
Drug-induced arthritis	Polyarticular^[7]
Ligamentous laxity	Polyarticular^[7]
Osteoarthritis	Monoarticular^[7]
Gout attack	Monoarticular^[7]	Hours^[11]
Pseudogout	Monoarticular^[7]
Behcet's Disease	Monoarticular^[7]
Physical trauma	Monoarticular^[7]	Immediate
Septic arthritis	Monoarticular^[7]	Hours^[11]
Hemarthrosis	Monoarticular^[7]
5HT2-antagonists^[12]
Henoch-Schonlein purpura^[13]

Diagnosis

Diagnosis involves interviewing the patient and performing physical exams. When attempting to establish the cause of the arthralgia, the emphasis is on the interview.^[2] The patient is asked questions intended to narrow the number of potential causes. Given the varied nature of these possible causes, some questions may seem irrelevant. For example, the patient may be asked about dry mouth, light sensitivity, rashes or a history of seizures.^[2]^[14] Answering yes or no to any of these questions limits the number of possible causes and guides the physician toward the appropriate exams and lab tests.

Treatment

Treatment depends on a specific underlying cause. The underlying cause will be treated first and foremost. The treatments may include joint replacement surgery for severely damaged joints, immunosuppressants for immune system dysfunction, antibiotics when an infection is the cause, and discontinuing medication when an allergic reaction is the cause. When treating the primary cause, pain management may still play a role in treatment.^[15]

References

^ "Arthralgia Definition". MedicineNet.com. Archived from the original on 11 October 2007. Retrieved 2007-09-20.
^ ^a ^b ^c Joe G. Hardin. "Arthralgia". Clinical Methods - The History, Physical, and Laboratory Examinations. Retrieved 2007-09-20.
^ James R Philp. "Allergic Drug Reactions - Systemic Allergic Drug Reactions". Clinical Methods - The History, Physical, and Laboratory Examinations. Retrieved 2007-09-20.
^ "MeSH". Retrieved 2007-12-23.
^ Joe G. Hardin. "Table 161.1. Some Common Regional Rheumatic Syndromes". Clinical Methods - The History, Physical, and Laboratory Examinations. Retrieved 2007-09-20.
^ Loris McVittie. "Information from CDC and FDA on the Safety of Gardasil Vaccine". supplement to your biologics license application (BLA) for Human Papillomavirus Quadrivalent (Types 6, 11, 16 and 18) Vaccine, Recombinant (GARDASIL), to include arthralgia, myalgia, asthenia, fatigue, and malaise in the Adverse Reactions section of the package insert. Retrieved 2008-07-21.
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l ^m ⁿ ^o ^p Table 6-8 in: Elizabeth D Agabegi; Agabegi, Steven S. (2008). Step-Up to Medicine (Step-Up Series). Hagerstwon, MD: Lippincott Williams & Wilkins. ISBN 978-0-7817-7153-5.
^ Diagnosis lag time of median 4 weeks, and median diagnosis lag time of 18 weeks, taken from: Chan, K. W.; Felson, D. T.; Yood, R. A.; Walker, A. M. (1994). "The lag time between onset of symptoms and diagnosis of rheumatoid arthritis". Arthritis and Rheumatism. 37 (6): 814–820. doi:10.1002/art.1780370606. PMID 8003053.
^ Doria, A.; Zen, M.; Canova, M.; Bettio, S.; Bassi, N.; Nalotto, L.; Rampudda, M.; Ghirardello, A.; Iaccarino, L. (2010). "SLE diagnosis and treatment: When early is early". Autoimmunity Reviews. 10 (1): 55–60. doi:10.1016/j.autrev.2010.08.014. PMID 20813207.
^ "Ehlers-Danlos syndrome - Symptoms and causes". Retrieved 10 February 2018.
^ ^a ^b Page 740 (upper right of page) in: Schaider, Jeffrey; Wolfson, Allan B.; Hendey, Gregory W.; Ling, Louis; Rosen, Carlo L. (2009). Harwood-Nuss' Clinical Practice of Emergency Medicine (Clinical Practice of Emergency Medicine (Harwood-Nuss)). Hagerstwon, MD: Lippincott Williams & Wilkins. ISBN 978-0-7817-8943-1.
^ Passier, Anneke; van Puijenbroek, Eugene (November 2005). "Mirtazapine-induced arthralgia". British Journal of Clinical Pharmacology. 60 (5): 570–572. doi:10.1111/j.1365-2125.2005.02481.x. PMC 1884949. PMID 16236049.
^ "Henoch-Schonlein purpura (video)". Khan Academy. Retrieved 2020-06-06.
^ "Table 159mptomatic Extraarticular Features of the Connective Tissue Diseases and the Spondyloarthropathies". Clinical Methods - The History, Physical, and Laboratory Examinations. Retrieved 2007-09-20.
^ "Pain Management". Arthritis Action UK. Arthritis Action. Archived from the original on 13 February 2016. Retrieved 16 October 2015.