The arrondissement of Grenoble was created in 1800.[4] At the January 2017 reorganisation of the arrondissements of Isère, it lost 24 communes to the arrondissement of Vienne.[5]
As a result of the reorganisation of the cantons of France which came into effect in 2015, the borders of the cantons are no longer related to the borders of the arrondissements. The cantons of the arrondissement of Grenoble were, as of January 2015:[6]