Antony Galione

Antony Galione
FRS FMedSci
Galione in 2016
Born (1963-09-13) 13 September 1963 (age 61)[4]
Chelmsford, England
EducationFelsted School
Alma materTrinity College, Cambridge
Spouse
Angela Clayton
​
(m. 1992)​
[4]
AwardsNovartis Prize (2001)[1]
Scientific career
Fields
Institutions
ThesisOscillations in intracellular calcium in the blowfly salivary gland (1989)
Doctoral advisorMichael Berridge[3]
Websitepharm.ox.ac.uk/team/antony-galione

Antony Giuseppe Galione (born 13 September 1963)[4] is a British pharmacologist. He is a professor and Wellcome Trust senior investigator in the Department of Pharmacology at the University of Oxford.[3]

Early life and education

Antony Giuseppe Galione was born on 13 September 1963 in Chelmsford, England, to Angelo and Margaret Galione.[4] He was educated at Felsted School[4] in Essex and Trinity College, Cambridge, where he was awarded a Bachelor of Arts degree in Natural Sciences (Pharmacology) in 1985[3] followed by a PhD in 1989 for research on calcium signalling in the salivary gland of the blowfly, supervised by Michael Berridge.[5][6]

Research and career

Galione's research investigates calcium signalling.[2] HC Lee established the concept of multiple calcium mobilising messengers which link cell surface stimuli to release of internal calcium stores, while Zhu, Evans and co-workers identified their target two-pore channels (TPCs) and organelles.[7] This has enhanced our understanding of how calcium as a ubiquitous cellular regulator may control a myriad of cellular processes with precision.[8]

Galione established that cyclic ADP-ribose regulates calcium-induced calcium release and globalisation of calcium signals,[9] and that Nicotinic acid adenine dinucleotide phosphate (NAADP) is a ubiquitous trigger for initiating and co-ordinating calcium signals, often involving communication between organelles at contact sites.[8]

By developing novel pharmacological, molecular and physiological approaches, he has demonstrated that these messengers and their targets regulate many fundamental pathophysiological cellular processes as diverse as Ebola virus disease infection, fertilisation and embryology, cardiac contractility, T cell activation and neuronal excitability. The discovery of lysosomes as calcium stores mobilised by NAADP has identified an entirely new signalling role for these organelles in health and disease.[8][10]

Galione served as head of the Department of Pharmacology at the University of Oxford from 2006 until 2015.[11]

Awards and honours

Galione was elected a Fellow of the Academy of Medical Sciences (FMedSci) in 2010[8] a Fellow of the Royal Society (FRS) in 2016.[8] He was awarded the Novartis Prize from the British Pharmacological Society in 2001.[1]

References

  1. ^ a b "Novartis Prize". bps.ac.uk. British Pharmacological Society. Archived from the original on 4 August 2017. Retrieved 3 August 2017.
  2. ^ a b Antony Galione publications indexed by Google Scholar
  3. ^ a b c "Professor Antony Galione FMedSci FRS". Oxford: University of Oxford. Archived from the original on 23 March 2016.
  4. ^ a b c d e "Galione, Prof. Antony Giuseppe". Who's Who. A & C Black. 2021. doi:10.1093/ww/9780199540884.013.U246727. (Subscription or UK public library membership required.)
  5. ^ Galione, Antony Giuseppe (1989). Oscillations in intracellular calcium in the blowfly salivary gland (PhD thesis). University of Cambridge. OCLC 53486297.
  6. ^ Berridge MJ, Galione A (1988). "Cytosolic calcium oscillators". The FASEB Journal. 2 (15): 3074–82. doi:10.1096/fasebj.2.15.2847949. PMID 2847949. S2CID 21782086.
  7. ^ Calcraft, Peter J.; Ruas, Margarida; Pan, Zui; Cheng, Xiaotong; Arredouani, Abdelilah; Hao, Xuemei; Tang, Jisen; Rietdorf, Katja; Teboul, Lydia; Chuang, Kai-Ting; Lin, Peihui; Xiao, Rui; Wang, Chunbo; Zhu, Yingmin; Lin, Yakang; Wyatt, Christopher N.; Parrington, John; Ma, Jianjie; Evans, A. Mark; Galione, Antony; Zhu, Michael X. (2009). "NAADP mobilizes calcium from acidic organelles through two-pore channels". Nature. 459 (7246): 596–600. Bibcode:2009Natur.459..596C. doi:10.1038/nature08030. PMC 2761823. PMID 19387438.
  8. ^ a b c d e Anon (2016). "Professor Antony Galione FMedSci FRS". London: Royal Society. Archived from the original on 29 April 2016. One or more of the preceding sentences incorporates text from the royalsociety.org website where:

    "All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License." --"Royal Society Terms, conditions and policies". Archived from the original on 25 September 2015. Retrieved 9 March 2016.{{cite web}}: CS1 maint: bot: original URL status unknown (link)
  9. ^ Galione, A.; Lee, H.; Busa, W. (1991). "Ca(2+)-induced Ca2+ release in sea urchin egg homogenates: modulation by cyclic ADP-ribose". Science. 253 (5024): 1143–1146. Bibcode:1991Sci...253.1143G. doi:10.1126/science.1909457. PMID 1909457. S2CID 43565315.
  10. ^ Arredouani A, Ruas M, Collins SC, Parkesh R, Clough F, Pillinger T, et al. (2015). "Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Endolysosomal Two-pore Channels Modulate Membrane Excitability and Stimulus-Secretion Coupling in Mouse Pancreatic β Cells". Journal of Biological Chemistry. 290 (35): 21376–92. doi:10.1074/jbc.M115.671248. PMC 4571866. PMID 26152717. Open access icon
  11. ^ "Antony Galione". University of Oxford. Archived from the original on 4 August 2017. Retrieved 3 August 2017.