Wesson committed to Ohio State under head coach Thad Matta on April 13, 2016.[2] After Matta was fired by Ohio State, Wesson stayed committed to Ohio State and new coach Chris Holtmann over offers from Butler (Holtmann's previous team), Xavier, and Akron.[3][4]
Wesson played in 29 games and averaged 2.3 points and 11.1 minutes per game.[5]
He had his season–high points record against Purdue, scoring 13 points. He averaged 2.9 points and 18.5 minutes per game.[5]
Wesson broke out during his junior season, averaging 8.6 points, 4.1 rebounds, and 30.0 minutes per game while starting 34 out of 35 games.[5][6] He scored a career–high 22 points against Purdue.[7]
His senior season was his best, starting 23 out of 29 games and averaging 9.2 points, 3.9 rebounds, and 30.9 minutes per game.[5] He scored a season high 19 points against Morgan State[8] His college career was cut short due to the COVID-19 pandemic.[6]