Her first top level performances came in cross country and she finished eighth in the short race at the 2002 IAAF World Cross Country Championships in Dublin, a placing which helped the women's Ethiopian team (including Werknesh Kidane, Abebech Negussie and Genet Gebregiorgis) to the gold medal in the team competition.[2] She competed in track races in Europe in the 2003–2004 and among her performances was a 5000 metres personal best of 15:19.50, set at the Grand Prix Regione Lombardia in 2004 where she finished fourth.[3] That year she also represented her country at the World Cross Country Championships for a second time, although her eleventh-place finish left her out of the top four Ethiopians who took the team gold.[4]
Amane made her debut in the marathon in January 2009 at the Houston Marathon and she managed to finish in fifth place.[11] At the Ras Al Khaimah Half Marathon the following month she set a personal best of 1:08:16 to take sixth place in the women's race.[12] Her next outing came at the Los Angeles Marathon in March and she headed to the front of the pack, but was overtaken by Tatyana Petrova in the latter stages of the race. Still, her time of 2:26:53 for second place marked a successful transition to the longer distance.[13] She competed extensively in the United States that summer, starting with wins at the Cooper River Bridge Run and Monument Avenue 10K. A fifth place at the Peachtree Road Race was followed up by a third-place finish at the Boilermaker Road Race. Amane ran her third marathon of the year at the Toronto Waterfront Marathon. She duelled against Mulu Seboka, another Ethiopian runner and the defending champion, in the earlier stages but then pulled away around the 40 km to earn her first win over the distance, breaking the course record with a run of 2:28:30 in the process.[14] She brought a busy year to a close with two runs in September, taking eighth at the Delhi Half Marathon before securing the runner-up position behind Koreni Jelila at the Great Ethiopian Run 10K.[15][16]
She gained her first high-profile win in the half marathon at the Göteborgsvarvet that May.[21] She then returned to the United States for the summer circuit, running at the Freihofer's Run for Women (eighth) and the Bolder Boulder, where she completed an Ethiopian 1–2 behind Mamitu Daska.[1][22] She was third at the Istanbul Eurasia Marathon as her national rival Ashu Kasim won in a course record time.[23] She won the Xiamen Marathon in January 2011 in her first race of the year.[24] She attempted to defend her title in Seoul, but was unsuccessful as she ended the race in tenth place.[25]
Amane missed 18 months of competition and return in November 2012 with a runner-up finish at the Istanbul Marathon.[26] The following January she ran a personal best at the 2013 Dubai Marathon, taking third with her run of 2:23:50 hours. She placed seventh at the Paris Marathon and came third at the Bogotá Half Marathon.[27]