Diomedes became Prime Minister upon the death of Sophoulis. It was during his brief term in office (28 June 1949 – 6 January 1950) that the Greek Civil War was concluded. He was forced to resign amid a scandal involving his Minister for Transport, Hatzipanos. He died later in that same year (11 November 1950).
Personal life
Besides being an economist and politician, Diomedes also authored several literary works, including a two-volume work on Byzantine Empire studies.
Along with his wife Julia, Diomidis left part of his fortune to the Greek state for the purposes of establishing a botanical garden in Athens, opened in 1952 as the "Julia and Alexander N. Diomides Botanic Garden".