Ruspoli's first marriage, in Rome on 8 December 1947, was to Nobile Francesca dei Baroni Blanc (Rome, 27 June 1920 – Milan, 27 February 1962), daughter of Nobile Mario dei Baroni Blanc and wife Anita Felici. They had no children.[citation needed]
Ruspoli's second marriage at Vignanello, the location of the ancestral residence, Castello Ruspoli, on 5 May 1964, was to French aristocrat Nancy de Girard de Charbonnières (Pouillon, 18 April 1939 –), daughter of Roger Jean de Girard de Charbonnières and wife Andrée Marie Pommarède. The marriage produced one son:
Don Francesco, Principe Ruspoli (Rome, 31 May 1967), being 10th Prince of Cerveteri and head of the Ruspoli family since the death of his father in 2005
Ruspoli's third marriage was also in Rome, on 20 November 1993, to Theresa Patricia Genest. This marriage produced a daughter and a son:
Bartolomeo dei Principi Ruspoli (Rome, 6 October 1978 –), married in November 2004 Aileen Getty (14 July 1957), daughter of John Paul Getty, Jr. and first wife Abigail "Gail" Harris, without issue.