Hofmann studied geology and geochemistry in Freiburg in Germany, and completed his PhD degree at Brown University from 1962 - 1968. His thesis on hydrothermal experiments on partitioning and diffusion of alkali metals in biotite-alkali chloride solutions was awarded in 1969.[4]
Hofmann uses trace elements and isotopic compositions of basalts to study the composition and evolution of Earth's mantle.[5] He recognized "canonical" trace element ratios as tools to distinguish recycling processes of ancient oceanic and continental crust through the mantle and showed that the chemical heterogeneity of the mantle is dominated by recycled ocean crust.