The river rises in the Litchfield National Park and flows generally northwards to Clarence Strait, joined by eight tributaries including the west branch of the Adelaide River, Coomalie Creek, Margaret River and Marrakai Creek, before discharging into its mouth in Adam Bay in the Clarence Strait. The river descends 151 metres (495 ft) over its 238-kilometre (148 mi) course.[1] The catchment area of the river is 7,640 square kilometres (2,950 sq mi).[2]
Lieutenant Fitzmaurice, under the command of John Lort Stokes, sighted the river on a boating expedition. The expedition was part of the Admiralty surveying ship HMS Beagle's voyage in 1839, and the river was named in honour of Queen Adelaide.[4]